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  1. No Access

    Article

    Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord

    **g Yang, Shulan **e, Shengmei Zhu, Zhen-Zhong Xu in Neuroscience Bulletin (2023)

  2. No Access

    Article

    Resolution of Inflammatory Pain by Endogenous Chemerin and G Protein-Coupled Receptor ChemR23

    Ya-Kai **e, Hao Luo, **ao-Yun Qiu, Zhen-Zhong Xu in Neuroscience Bulletin (2021)

  3. No Access

    Article

    The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain

    Zilong Wang, Zhen-Zhong Xu in Neuroscience Bulletin (2021)

  4. No Access

    Article

    Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

    Toll-like receptor 5 (TLR5) expression is found to be enriched in mouse dorsal root ganglion (DRG) A-fiber neurons known to mediate mechanical allodynia, a form of chronic neuropathic pain. Selective silencing...

    Zhen-Zhong Xu, Yong Ho Kim, Sangsu Bang, Yi Zhang, Temugin Berta… in Nature Medicine (2015)

  5. No Access

    Article

    Resolvin E1 Inhibits Neuropathic Pain and Spinal Cord Microglial Activation Following Peripheral Nerve Injury

    Accumulating evidence indicates that activation of spinal cord microglia plays an important role in the genesis of neuropathic pain. Resolvin E1 (E1) is derived from omega-3 polyunsaturated fatty acid and exhi...

    Zhen-Zhong Xu, Temugin Berta, Ru-Rong Ji in Journal of Neuroimmune Pharmacology (2013)

  6. Article

    Open Access

    Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9

    Activation of spinal cord glial cells such as microglia and astrocytes has been shown to regulate chronic opioid-induced antinociceptive tolerance and hyperalgesia, due to spinal up-regulation of the proinflam...

    Temugin Berta, Tong Liu, Yen-Chin Liu, Zhen-Zhong Xu, Ru-Rong Ji in Molecular Pain (2012)

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  7. No Access

    Article

    Toll-like receptor 7 mediates pruritus

    Liu and colleagues report that toll-like receptor 7 (TLR7), which is typically thought to be expressed in immune cells and to function to regulate innate immunity, is expressed and acts in C-fiber primary sens...

    Tong Liu, Zhen-Zhong Xu, Chul-Kyu Park, Temugin Berta, Ru-Rong Ji in Nature Neuroscience (2010)

  8. No Access

    Article

    Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

    The omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid alleviate inflammatory pain in patients. Ru-Rong Ji and his colleagues find that the resolvins RvE1 and RvD1, which are derived from omega...

    Zhen-Zhong Xu, Ling Zhang, Tong Liu, Jong Yeon Park, Temugin Berta… in Nature Medicine (2010)

  9. No Access

    Article

    Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

    Treatment of neuropathic pain, triggered by multiple insults to the nervous system, is a clinical challenge because the underlying mechanisms of neuropathic pain development remain poorly understood1,2,3,4. Most ...

    Yasuhiko Kawasaki, Zhen-Zhong Xu, **aoying Wang, Jong Yeon Park… in Nature Medicine (2008)