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  1. No Access

    Article

    Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

    Toll-like receptor 5 (TLR5) expression is found to be enriched in mouse dorsal root ganglion (DRG) A-fiber neurons known to mediate mechanical allodynia, a form of chronic neuropathic pain. Selective silencing...

    Zhen-Zhong Xu, Yong Ho Kim, Sangsu Bang, Yi Zhang, Temugin Berta… in Nature Medicine (2015)

  2. No Access

    Article

    Emerging targets in neuroinflammation-driven chronic pain

  3. Chronic pain cannot be effectively treated using current drugs such as opioids and non-steroidal anti-inflammatory drugs (NSAIDs).

    4. ...

    Ru-Rong Ji, Zhen-Zhong Xu, Yong-**g Gao in Nature Reviews Drug Discovery (2014)

  4. No Access

    Article

    Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

    The omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid alleviate inflammatory pain in patients. Ru-Rong Ji and his colleagues find that the resolvins RvE1 and RvD1, which are derived from omega...

    Zhen-Zhong Xu, Ling Zhang, Tong Liu, Jong Yeon Park, Temugin Berta… in Nature Medicine (2010)

  5. No Access

    Article

    Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

    Treatment of neuropathic pain, triggered by multiple insults to the nervous system, is a clinical challenge because the underlying mechanisms of neuropathic pain development remain poorly understood1,2,3,4. Most ...

    Yasuhiko Kawasaki, Zhen-Zhong Xu, **aoying Wang, Jong Yeon Park… in Nature Medicine (2008)