350 Result(s)
within
Zhen**g Yang
Life Sciences
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Article
Open AccessIntegrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma
The expression dysregulation of microRNAs (miRNA) has been widely reported during cancer development, however, the underling mechanism remains largely unanswered. In the present work, we performed a systematic...
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Erratum to: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival
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The LasmiR858-MYB111 module enhances the antioxidant capacity of green leaf lettuce by promoting flavonoid biosynthesis
Flavonoids are secondary metabolites found in plants that possess antioxidant properties. MicroRNAs are small non-coding RNAs that play a crucial role in regulating gene expression and are involved in both dev...
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Open AccessTagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing
The massive structural variations and frequent introgression highly contribute to the genetic diversity of wheat, while the huge and complex genome of polyploid wheat hinders efficient genoty** of abundant v...
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Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
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Identification of LRRC46 as a novel candidate gene for high myopia
High myopia (HM) is the primary cause of blindness, with the microstructural organization and composition of collagenous fibers in the cornea and sclera playing a crucial role in the biomechanical behavior of ...
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Open AccessMIR396-GRF/GIF enhances in planta shoot regeneration of Dendrobium catenatum
Recent studies on co-transformation of the growth regulator, TaGRF4-GIF1 chimera (Growth Regulating Factor 4-GRF Interacting Factor 1), in cultivated wheat varieties (Triticum aestivum), showed improved regenerat...
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Open AccessLncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination
A long-standing hypothesis proposes that certain RNA(s) must exhibit structural roles in microtubule assembly. Here, we identify a long noncoding RNA (TubAR) that is highly expressed in cerebellum and forms RNA–p...
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Open AccessLncRNA NUTM2A-AS1 silencing inhibits glioma via miR-376a-3p/YAP1 axis
The lncRNA NUTM2A-AS1 has been shown to be dysregulated in gastric cancer, while the roles in glioma is unclear. The aim of this study was to investigate the roles and potential mechanisms of lncRNA NUTM2A-AS1...
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Reduction of nutrient fluxes across the sediment–water interface and nutrient accumulation in lotus-fish co-culture aquaculture ponds
Continuously feed-based aquaculture leads to excessive nitrogen and phosphate loads, degrading the culture environment. In this study, lotus (Nelumbo nucifera Gaertn) was planted in yellow catfish (Pelteobagrus f...
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IRE1α: from the function to the potential therapeutic target in atherosclerosis
Inositol requiring enzyme 1 (IRE1) is generally thought to control the most conserved pathway in the unfolded protein response (UPR). Two isoforms of IRE1, IRE1α and IRE1β, have been reported in mammals. IRE1α...
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Open AccessPeNAC67-PeKAN2-PeSCL23 and B-class MADS-box transcription factors synergistically regulate the specialization process from petal to lip in Phalaenopsis equestris
The molecular basis of orchid flower development involves a specific regulatory program in which MADS-box transcription factors play a central role. The recent ‘perianth code’ model hypothesizes that two types...
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Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p
Chronic liver damage (CLD) encompasses a spectrum of conditions and poses a significant global health challenge, affecting millions of individuals. Currently, there is a deficiency of clinically validated ther...
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Open AccessSequence characteristics, genetic diversity and phylogenetic analysis of the Cucurbita ficifolia (Cucurbitaceae) chloroplasts genome
Curcubita ficifolia Bouché (Cucurbitaceae) has high value as a food crop and medicinal plant, and also has horticultural value as rootstock for other melon species. China is home to many different cultivars, but ...
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Priming effects by cellulose inputs decrease with warming regardless of the decomposition stages of soil carbon pools
Soil comprises diverse carbon (C) pools undergoing various decomposition stages, each characterized by distinct stability and turnover rates. The response of these C pools to warming with the input of plant re...
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Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity
Vicenistatin (1) is a 20-membered polyketide macrocyclic antibiotic with potent antimicrobial and cytotoxic activities. In this study, to further explore the potential of 1 as candidates of antibacterial drug dev...
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Spatial imaging of glycoRNA in single cells with ARPLA
Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently discovered class of glycosylated molecules, because of a lack of visualization methods. We report sialic acid aptamer and...
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Comparative analysis of the economic feasibility of Tiger puffer (Takifugu rubripes) aquaculture in China
Tiger puffer (Takifugu rubripes) is one of the most expensive farmed marine fish species in China. The high profitability of farmed tiger puffer is used to attract many new investors. However, some investments...
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Open AccessCausal association of obesity with epigenetic aging and telomere length: a bidirectional mendelian randomization study
In observational studies, there exists an association between obesity and epigenetic age as well as telomere length. However, varying and partially conflicting outcomes have notably arisen from distinct studie...
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Open AccessmTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA
Osteosarcoma (OS) is considered a sex steroid hormone-dependent bone tumor. The development and progression of OS are regulated by 17β-estradiol (E2). However, the detailed mechanisms of E2-modulated OS progre...
