65 Result(s)

Article

Prognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy

The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...

Cheng-Fei Du, Zhen-Yu Gao, Zhu-Ding Xu, Zheng-Kang Fang, Zi-Chen Yu… in BMC Cancer (2024)

Article

Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer

The efficacy of anti-PD-1 therapy is primarily hindered by the limited T-cell immune response rate and immune evasion capacity of tumor cells. Autophagy-related protein 7 (ATG7) plays an important role in auto...

Wenxin Zhang, Lu Chen, Jiafeng Liu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib

Pancreatic adenocarcinoma (PC) is an aggressive malignancy with limited treatment options. The poor prognosis primarily stems from late-stage diagnosis and when the disease has become therapeutically challengi...

Weiyu Ge, Yanling Wang, Ming Quan, Tiebo Mao, Evelyne Y. Bischof… in Molecular Cancer (2024)

Article

Exploration and validation of a novel signature of seven necroptosis-related genes to improve the clinical outcome of hepatocellular carcinoma

Necroptosis has been reported to be involved in cancer progression and associated with cancer prognosis. However, the prognostic values of necroptosis-related genes (NRGs) in hepatocellular carcinoma (HCC) rem...

Qiqi Tao, Zhichao Lang, Yifei Li, Yuxiang Gao, Lifan Lin, Zheng** Yu… in BMC Cancer (2023)

Article

Correction: Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

Yulin Peng, Yan Wang, Ning Tang… in Journal of Experimental & Clinical Cancer … (2023)

Article

Correction: Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

Zhenlong Yu, Wei Guo, **aochi Ma, Bao**g Zhang, Peipei Dong, Lin Huang… in Molecular Cancer (2023)

Article

High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis

PTPRF interacting protein alpha 1 (PPFIA1) is reportedly related to the occurrence and progression of several kinds of malignancies. However, its role in esophageal squamous cell carcinoma (ESCC) is unclear. T...

Yongyin Gao, Lizhao Guan, Ran Jia, Wanyi **ao, Youming Han, Yue Li, Peng Tang… in BMC Cancer (2023)

Article

Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions

Cancer testis antigens (CTAs) are optimal tumor diagnostic markers and involved in carcinogenesis. However, colorectal cancer (CRC) related CTAs are less reported with impressive diagnostic capability or relev...

Shengnan Ren, Dingquan Yang, Yongli Dong, Weidong Ni, Meiqi Wang… in Cellular Oncology (2023)

Article

Machine learning integrations develop an antigen-presenting-cells and T-Cells-Infiltration derived LncRNA signature for improving clinical outcomes in hepatocellular carcinoma

As a highly heterogeneous cancer, the prognostic stratification and personalized management of hepatocellular carcinoma (HCC) are still challenging. Recently, Antigen-presenting-cells (APCs) and T-cells-infilt...

**aodong Wang, Ji Chen, Lifan Lin, Yifei Li, Qiqi Tao, Zhichao Lang… in BMC Cancer (2023)

Article

A comprehensive study based on exosome-related immunosuppression genes and tumor microenvironment in hepatocellular carcinoma

Exosomes play an important role in the tumor microenvironment (TME) and the mechanisms of tumor immune escape in hepatocellular carcinoma (HCC). It is known that immunosuppressive genes, involved in the proces...

Zhan Yang, **nmiao Li, Chaoran Pan, Yifei Li, Lifan Lin, Yan **… in BMC Cancer (2022)

Article

Comparison of clinicopathological features and prognostic significance between synchronous multiple primary and solitary esophageal squamous cell carcinomas

Synchronous multiple primary esophageal squamous cell carcinoma (S-MPESCC) refers to more than one primary esophageal carcinoma detected in a solitary patient at the time of initial presentation. The purpose o...

Yueyang Yang, Peng Tang, Mingquan Ma, Hongdian Zhang, Haitong Wang, Kai Zhu… in BMC Cancer (2022)

Article

M6A-related lncRNAs predict clinical outcome and regulate the tumor immune microenvironment in hepatocellular carcinoma

LncRNA N6-methylandenosine (m6A) modification has been shown to be associated with the constitution of the tumor microenvironment (TME) and tumorigenesis. It’s essential to understand the mechanisms of lncRNA ...

Bo Chen, Zhan Yang, Zhichao Lang, Qiqi Tao, Rongrong Zhang, Yating Zhan… in BMC Cancer (2022)

Article

Application of circulating tumour cells to predict response to treatment in head and neck cancer

Local recurrence and metastasis remain the major causes of death in head and neck cancer (HNC) patients. Circulating tumour cells (CTCs) are shed from primary and metastatic sites into the circulation system a...

** Zhang, Chameera Ekanayake Weeramange, Brett G. M. Hughes… in Cellular Oncology (2022)

Article

MARCKSL1–2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b

Long non-coding RNAs (lncRNAs) are implicated in the development of multiple cancers. In our previous study, we demonstrated that HDAC1/4-mediated silencing of microRNA-200b (miR-200b) enhances docetaxel (DTX)...

Min Jiang, Feng Qi, Kai Zhang, **aofei Zhang, **g**g Ma, Suhua **a… in Molecular Cancer (2022)

Article

Current status of neoadjuvant therapy for locally advanced rectal cancer in Wuhan Union Hospital Cancer Center

To analyze and explore the evolution and short-term efficacy of neoadjuvant therapy for patients with mid and low LARC in Wuhan Union Hospital Cancer Center.

Meng-Lan Zhai, Fang-Yuan Zhang, **-Ru Yang, Sheng Zhang, Lei Zhao… in Radiation Oncology (2022)

Article

Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma

Osteosarcoma (OS) is a malignant bone tumor mostly occurring in children and adolescents, while chemotherapy resistance often develops and the mechanisms involved remain challenging to be fully investigated.

Mingrui Du, **tao Gu, Chenlin Liu… in Journal of Experimental & Clinical Cancer … (2022)

Article

Prognostic significance of the skeletal muscle index and systemic inflammatory index in patients with lymph node-positive breast cancer after radical mastectomy

The role of skeletal muscle index (SMI) and systemic inflammation index (SII) for patients with lymph node-positive breast cancer remain controversial. This retrospective study aims to evaluate the individual ...

Ru Tang, Jia-Peng Deng, Lei Zhang, Wen-Wen Zhang, Jia-Yuan Sun, Feng Chi… in BMC Cancer (2022)