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Article
Open AccessInheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes
Undernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we foun...
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Article
Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy
Mitochondrial replacement therapy (MRT) has been used to prevent maternal transmission of disease-causing mutations in mitochondrial DNA (mtDNA). However, because MRT requires nuclear transfer, it carries the ...
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Article
Open AccessRepeated superovulation may affect mitochondrial functions of cumulus cells in mice
Controlled ovarian stimulation by exogenous gonadotrophins is a key procedure during the in vitro fertilization cycle to obtain a sufficient number of oocytes in humans. Previous studies demonstrated that repeate...
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Article
Optimum oocyte retrieved and transfer strategy in young women with normal ovarian reserve undergoing a long treatment protocol: a retrospective cohort study
This study aimed to investigate the relationship between the number of oocytes retrieved and clinical outcomes in young women with normal ovarian reserve who were undergoing their first in vitro fertilization ...
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Article
Open AccessMaternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in mice
The adverse effects on offspring of diabetic and/or obese mothers can be passed to the next generation. However, the mechanisms behind this are still unclear. Epigenetics may play a key role during this process.
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Article
Open AccessDiabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice
Maternal diabetes mellitus not only has severe deleterious effects on fetal development, but also it affects transmission to the next generation. However, the underlying mechanisms for these effects are still ...
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Article
Open AccessMaternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development
The adverse effects of maternal diabetes on oocyte maturation and embryo development have been reported.
