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  1. Article

    Open Access

    The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

    Transforming growth factor-β (TGFβ) signaling is initiated by the type I, II TGFβ receptor (TβRI/TβRII) complex. Here we report the formation of an alternative complex between TβRI and the orphan GPR50, belong...

    Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair… in Nature Communications (2018)

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  2. No Access

    Article

    Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas

    Inactivating mutations in ACTRT1 or surrounding noncoding sequences transcribed into functional enhancer RNAs cause aberrant activation of Hedgehog signaling in both sporadic and inherited forms, such as Bazex–Du...

    Elodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, Hülya Kayserili… in Nature Medicine (2017)

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    Article

    HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

    In human β-thalassaemiaerythroblasts, HSP70 is sequestered in the cytoplasm by the excess of free α-globin chains and can no longer protect the master transcriptional factor of erythropoiesis GATA-1 from caspa...

    Jean-Benoît Arlet, Jean-Antoine Ribeil, Flavia Guillem, Olivier Negre… in Nature (2014)