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Nociceptin-induced histamine release in the brain: comparison with compound 48/80- and substance P-induced amine secretions
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Stimulating effect of nociceptin on histamine release in the rat brain?
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Low levels of antibodies against E. coli and mycobacterial 65kDa heat shock proteins in patients with inflammatory bowel disease
Objective and design: The aim of the present study was to support and extend our initial observation, where we found low levels of antibodies against mycobacterial 65kD heat shock proteins in patients with inflam...
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Article
Histamine uptake into non-neuronal brain cells
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Histamine (HA) suppresses the production of tumor necrosis factor alpha (TNFα) in cultured astroglial cells
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Article
Histamine-sensitive86Rb transport in cultured type-2 astrocytes of rat brain
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Ouabain-insensitive86Rb+ transport in peritoneal mast cells: Role in histamine release
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Article
Mechanism and function of histamine-sodium cotransport by astroglial cells
There is a saturable and high affinity uptake system for histamine in astroglial cells. The uptake is metabolically driven, sodium dependent and electrogenic. We consider the functional significance of these f...
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Article
Evidence for a regulatory role of a phosphorylation-dephosphorylation cycle in hypothalamic and lung histidine decarboxylase (HisDC) activity
To investigate the modulation of histidine decarboxylase (HisDC) activity by the degree of phosphorylation of a modulatory (or enzyme) protein, HisDC was partially purified from the cytosol of the hypothalamus...
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Article
Characterization of potassium channels in mast cell plasma membranes: Their possible existence and involvement in potassium-evoked histamine release
The effects of three K+-channel blockers, quinine, quinidine and sparteine on K+-evoked histamine (HA) release have been investigated. KCl (150 mM) initiated 40–55% release of HA from rat peritoneal mast cells in...
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Article
Contribution of glial cells to histamine inactivation
dl-α-aminoadipic acid (dl-αAA), a selective gliotoxic agent produced significant reductions in histamine-N-methyl-transferase (HNMT) and monoamine oxidase-B (MAO-B) activities and an enhancement in histamine (HA...
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Article
The effect of a new antihistamine drug, Loderix® (EGIS-2062), on stimulus-evoked histamine release from rat peritoneal mast cells
The ability of a new, non-sedative antihistamine drug, Loderix® (EGIS-2062), to inhibit stimulusevoked histamine release from rat peritoneal mast cells has been investigated and compared with that of ketotifen (Z...
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Article
Potassium-induced histamine release from mast cells and its inhibition by ketotifen
Potassium chloride induced a dose-dependent release of histamine from rat peritoneal mast cells at concentrations from 5 to 150 mM in the absence of extracellular Ca2+. Potassium concentrations greater than 150 m
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Article
Stimulation of hypothalamic histidine decarboxylase by calcium-calmodulin and protein kinase (cAMP-dependent) inhibitor
Stimulatory effects of Ca2+−CaM* and PKI on partially purified hypothalamic HD (10 fold purification) have been shown under conditions involving inhibition of the enzyme by cAMP-induced phosphorylation and under ...
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Evidence for the role of cAMP-dependent protein kinase in the down-regulation of hypothalamic HD: Reversal of cAMP-(ATP) induced inhibition of HD activity by the ‘Walsh’ inhibitor of cAMP-dependent protein kinase and by cyclic GMP
Under the total blockade of PDE1 and the presence of endogeneous ATP and MgCl2, the inhibitory effect of cAMP on HD activity could be demonstrated as low as 8.7×10−8 M concentration in a 20,000 g supernatant of a...
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Recent status of histamine in the brain
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The European Histamine Research Society
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Additional data on the function of hypothalamic histamine
In a preliminary study, the stimulatory effect of histamine on an adenylate cyclase system in a solubilized cell-free preparation of the rat hypothalamus was established. The effect was dose dependent, and the...
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Induction of gastric histamine synthesis by H2-receptor antagonists: Potentiation of their antisecretory activity by histidine decarboxylase inhibitors
The activation of histamine (HA) formation in rat stomach was measured after repeated administrations of histamine H2-receptor antagonists and the potentiation of their antisecretory activity was examined in hist...
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Article
Effects ofl-histidine administration on the concentrations of histidine and histamine in various tissues