-
Article
Open AccessAn Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3
Zic3 encodes a zinc finger protein essential for the development of meso-ectodermal tissues. In mammals, Zic3 has important roles in the development of neural tube, axial skeletons, left-right body axis, and in m...
-
Article
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures
GABAergic interneurons are highly heterogeneous, and much is unknown about the specification and functional roles of their neural circuits. Here we show that a transinteraction of Elfn1 and mGluR7 controls tar...
-
Article
Open AccessZic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients
ZIC2 is a causal gene for holoprosencephaly and encodes a zinc-finger-type transcriptional regulator. We characterized Zic2kd/+ mice with a moderate (40%) reduction in Zic2 expression. Zic2kd/+ mice showed increa...
-
Article
Open AccessExpression of ZIC family genes in meningiomas and other brain tumors
Zic zinc finger proteins are present in the develo** rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human ZIC genes are known to be molecular mark...
-
Article
Open AccessDicyema Pax6 and Zic: tool-kit genes in a highly simplified bilaterian
Dicyemid mesozoans (Phylum Dicyemida) are simple (8–40-cell) cephalopod endoparasites. They have neither body cavities nor differentiated organs, such as nervous and gastrointestinal systems. Whether dicyemids...
