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  1. Article

    Open Access

    Neuroendocrine prostate cancer has distinctive, non-prostatic HOX code that is represented by the loss of HOXB13 expression

    HOX gene-encoded homeobox proteins control body patterning during embryonic development; the specific expression pattern of HOX genes may correspond to tissue identity. In this study, using RNAseq data of 1019...

    Siyuan Cheng, Shu Yang, Yingli Shi, Runhua Shi, Yunshin Yeh… in Scientific Reports (2021)

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  2. No Access

    Article

    The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer

    After long-term androgen deprivation therapy, 25–30% prostate cancer (PCa) acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key transcription coactivator of the Hippo pathway, has...

    Siyuan Cheng, Nestor Prieto-Dominguez, Shu Yang… in Prostate Cancer and Prostatic Diseases (2020)

  3. No Access

    Chapter

    Wnt/Beta-Catenin Signaling and Prostate Cancer Therapy Resistance

    Metastatic or locally advanced prostate cancer (PCa) is typically treated with androgen deprivation therapy (ADT). Initially, PCa responds to the treatment and regresses. However, PCa almost always develops re...

    Yunshin Yeh, Qiaozhi Guo, Zachary Connelly, Siyuan Cheng, Shu Yang… in Prostate Cancer (2019)