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Article
Cloning and analysis of promoter region of mouse immunoglobulin germline γ3 transcripts
The germline γ3 transcripts (GLTγ3) is transcribed by mouse B cells following stimulation with lipopolysaccharide (LPS). GLTγ3 transcription is a prerequisite for IgG3 class switching. However, to date, the pr...
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Article
All-Trans-Retinoic Acid Rescues Neurons After Global Ischemia by Attenuating Neuroinflammatory Reactions
Retinoic acid (RA) plays an important role in the develo** mammalian nervous system. Based on this concept, some studies have demonstrated the beneficial effects of RA administration on neurogenesis in neuro...
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Article
Inhibitory effect of oral administration of Sangwhang mushroom (Phellinus linteus) grown on germinated brown rice on experimental lung metastasis and tumor growth in mice
Here, the effect of oral administration of the extract of sangwhang mushroom (Phellinus linteus, PL) grown on germinated brown rice on lung metastasis of tumor cells was examined in mice, and a possible immunolog...
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Article
Adjuvant activity of cudrania tricuspidata water extracts to enhance antigen specific humoral and cellular immune responses
The adjuvant effect of two types of water extracts of Cudrania tricuspidata (CT), cold water extract (CT-CW) and hot water extract (CT-HW), on induction of humoral and cellular immune responses against keyhole li...
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Article
Korean mistletoe lectin (KML-IIU) and its subchains induce nitric oxide (NO) production in murine macrophage cells
Synthesis of nitric oxide (NO) is one of the important effector functions of innate immune cells. Although several reports have indicated mistletoe lectins induce immune cells to produce cytokines, studies reg...
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Article
Isolation of fatty acids with anticancer activity fromProtaetia brevitarsis Larva
In this study, biologically active compounds were isolated fromProtaetia brevitarsis larva (PBL) by dichloromethane extraction. The dichloromethane extract from PBL was highly cytotoxic to various cancer cells. F...
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Article
Isolation ofepi-oleanolic acid from korean mistletoe and its apoptosis-lnducing activity in tumor cells
A triterpene was isolated as a cytotoxic principle from the dichloromethane extract of Korean mistletoe (KM;Viscum album coloratum) by repeated silica gel chromatography and recrystallization. Inin vitro analysis...
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Article
An antioxidant hispidin from the mycelial cultures ofPhellinus linteus
In the course of screening for reactive oxygen species scavengers from natural products, an antioxidant was isolated from the mycelial culture broth ofPhellinus linteus and identified as hispidin. The hispidin co...
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Article
Antitumor activity of the Korean Mistletoe Lectin is attributed to activation of macrophages and NK cells
Inhibitory effect of the lectins (KML-C) isolated from Korean mistletoe (KM;Viscum album coloratura) on tumor metastases produced by murine tumor cells (B16-BL6 melanoma, colon 26-M3.1 carcinoma and L5178Y-ML25 l...
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Article
Neuraminidase Inhibitors fromReynoutria elliptica
In the course of screening neuraminidase inhibitors from herbal medicines, Reynoutria elliptica exhibited high inhibitory activity. Four active compounds were isolated from the ethyl acetate soluble fraction b...
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Article
Immunomodulating and anticoagulant activity of glycosami-noglycans derived from porcine testis
Glycosaminoglycans (GAGs) were isolated from the porcine testis, and their immuno-modulating and anticoagulant activity was investigated. From anion exchange chromatography (Dowex Macropolous Resin) used for f...
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Article
Inhibitory effect of BCG cell-wall skeletons (BCG-CWS) emulsified in squalane on tumor growth and metastasis in mice
The antimetastatic effect of BCG-CWS, which was emulsified in an oil-in-water form with either Drakeol 6VR mineral oil (BCG-CWS/DK) or squalane (BCG-CWS/SQA), on lung metastasis produced by highly metastatic m...
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Article
Anticoagulant activity of sulfoalkyl derivatives of curdlan
Curdlan is a natural β-1, 3-glucan produced byAgrobacterium biovar 1. In this study, the anticoagulant activity of sulfoalkyl derivatives of curdlan was investigated by carrying out activated partial thromboplast...
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Article
Isolation and characterization of proteoglycan derived from human placenta and its biological activities
Chondroitin sulfates proteoglycans were isolated from human placenta. For the identification of enzymatic digestion products of isolated proteoglycan, strong anion exchange-high performance liquid chromatograp...
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Chapter
Bovine Lactoferrin and LactoferricinTM Inhibit Tumor Metastasis in Mice
The effect of a bovine milk protein, lactoferrin (bLf), and a pepsin-generated peptide of bLf, lactoferricin (Lfcin-B), on inhibition of tumor metastasis produced by highly metastatic murine tumor cells, B16-B...
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Article
Inhibition of tumor metastasis by Arg-Gly-Asp-Ser (RGDS) peptide conjugated with sulfated chitin derivative, SCM-chitin-RGDS
We have synthesized a new compound in which Arg-Gly-Asp-Ser (RGDS) was conjugated with 6-0-sulfated and 6-O-carboxymethyl-chitin (SCM-chitin), i.e. SCM-chitin-RGDS, and tested the inhibitory effect on lung and li...
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Chapter
Stimulation of Host-Defense Mechanism with Synthetic Adjuvants and Recombinant Cytokines Against Viral Infection in Mice
The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes sim...
