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Article
The Behavior of Phobic and Philip Oil Mist Filters Under High Pressure
The aim of this paper is to study the changing law of filter media properties under high-pressure conditions, and for this purpose, an experimental setup was established to measure the properties of filter mat...
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Article
Open AccessBiocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells
Glutamine synthetase (GS) is vital in maintaining ammonia and glutamate (Glu) homeostasis in living organisms. However, the natural enzyme relies on adenosine triphosphate (ATP) to activate Glu, resulting in i...
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Article
Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes
Mitochondrial proteases are emerging as key regulators of mitochondrial plasticity and acting as both protein quality surveillance and regulatory enzymes by performing highly regulated proteolytic reactions. H...
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Article
Open AccessGolgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy
Golgi apparatus (GA) oxidative stress induced by in situ reactive oxygen species (ROS) could severely damage the morphology and function of GA, which may open up an avenue for effective photodynamic therapy (P...
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Article
Open AccessDisuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength
Mitochondrial proteolysis is an evolutionarily conserved quality-control mechanism to maintain proper mitochondrial integrity and function. However, the physiological relevance of stress-induced impaired mitoc...
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Article
Rational Design of Ratiometric Fe3+ Fluorescent Probes Based on FRET Mechanism
As the most abundant transition metal element in mammals, iron(Fe) plays a vital role in life activities. It is of great significance to study the variation of Fe3+ level in living organisms. In virtue of the adv...
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Article
Open AccessRational construction of a reversible arylazo-based NIR probe for cycling hypoxia imaging in vivo
Reversible NIR luminescent probes with negligible photocytotoxicity are required for long-term tracking of cycling hypoxia in vivo. However, almost all of the reported organic fluorescent hypoxia probes report...
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Article
Open AccessJ-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging
J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challeng...
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Article
Open AccessSimultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells
Zn2+ plays important roles in metabolism and signaling regulation. Subcellular Zn2+ compartmentalization is essential for organelle functions and cell biology, but there is currently no method to determine Zn2+ s...
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Article
Open AccessRecent Endeavors on Molecular Imaging for Map** Metals in Biology
Transition metals such as zinc, copper and iron play vital roles in maintaining physiological functions and homeostasis of living systems. Molecular imaging, including two-photon imaging (TPI), bioluminescence...
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Article
A dual-modal probe for NIR fluorogenic and ratiometric photoacoustic imaging of Cys/Hcy in vivo
Biothiols, such as cysteine (Cys) and homocysteine (Hcy), play vital roles in biological homeostasis and are closely related to various pathological and physiological processes in the living systems. Therefore...
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Article
An active texture-based digital atlas enables automated map** of structures and markers across brains
Brain atlases enable the map** of labeled cells and projections from different brains onto a standard coordinate system. We address two issues in the construction and use of atlases. First, expert neuroanato...
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Article
A ratiometric fluorescent sensor for tracking Cu(I) fluctuation in endoplasmic reticulum
A two-photon ratiometric fluorescent sensor for Cu+ in endoplasmic reticulum (ER), CNSB, was developed via coumarin/ASBD integration based on FRET mechanism. In solution, CNSB shows reversible, highly-specific ra...
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Article
BODIPY-derived ratiometric fluorescent sensors: pH-regulated aggregation-induced emission and imaging application in cellular acidification triggered by crystalline silica exposure
Modification of classic fluorophore to possess the emission transitions between aggregation-induced emission (AIE) and intrinsic emission offers reliable approach to the design of ratiometric fluorescent senso...
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Article
Open AccessHighly sensitive switching of solid-state luminescence by controlling intersystem crossing
The development of intelligent materials, in particular those showing the highly sensitive mechanoresponsive luminescence (MRL), is desirable but challenging. Here we report a design strategy for constructing ...
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Article
Down-regulation of miRNA-451a and miRNA-486-5p involved in benzene-induced inhibition on erythroid cell differentiation in vitro and in vivo
Exposure to high-dose benzene leads to the inhibition of erythroid differentiation. However, whether lower doses of benzene exposure resemble high-dose effects in erythroid differentiation, as well as the unde...
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Chapter and Conference Paper
The Active Atlas: Combining 3D Anatomical Models with Texture Detectors
While modern imaging technologies such as fMRI have opened exciting possibilities for studying the brain in vivo, histological sections remain the best way to study brain anatomy at the level of neurons. The p...
