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  1. Article

    Open Access

    Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch

    Lysine-specific histone demethylase 1 (LSD1) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells (iPSCs). Here we reported that LS...

    Hao Sun, Lining Liang, Yuan Li, Chengqian Feng, Lingyu Li… in Scientific Reports (2016)

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    Article

    Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming

    Present practices for reprogramming somatic cells to induced pluripotent stem cells involve simultaneous introduction of reprogramming factors. Here we report that a sequential introduction protocol (Oct4–Klf4 fi...

    **aopeng Liu, Hao Sun, **g Qi, Linli Wang, Songwei He, **g Liu… in Nature Cell Biology (2013)

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    Article

    The N-terminal domain is a transcriptional activation domain required for Nanog to maintain ES cell self-renewal

    Nanog is a transcription factor identified by its ability to maintain the self-renewal of ES cells in the absence of leukemia inhibitory factor (LIF). Nanog protein contains an N-terminal domain (ND), a DNA-bi...

    YunQian Guo, Juan Zhang, Li Ye, Mo Chen, Dong Yao, Guang** Pan… in Chinese Science Bulletin (2009)