35 Result(s)

Article

Global fungal-host interactome map** identifies host targets of candidalysin

Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...

Tian-Yi Zhang, Yao-Qi Chen, **g-Cong Tan, **-An Zhou… in Nature Communications (2024)

Article

The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters

The piRNA pathway is essential for female fertility in golden hamsters and likely humans, but not in mice. However, the role of individual PIWIs in mammalian reproduction remains poorly understood outside of m...

**aolong Lv, Wen **ao, Yana Lai, Zhaozhen Zhang, Hongdao Zhang… in Nature Communications (2023)

Article

Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia

The genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such as tanshinones and carnosic acids, ...

Jiadong Hu, Shi Qiu, Feiyan Wang, Qing Li, Chun-Lei **ang, Peng Di… in Nature Communications (2023)

Article

Age-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis

The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments is known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, DNA fragments and RA patho...

Wei-Dan Luo, Yu-** Wang, Jun Lv, Yong Liu, Yuan-Qing Qu… in Nature Communications (2023)

Article

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni… in Nature (2023)

Article

Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in e...

Qing Li, Jiansen Lu, **di Yin, Yunjian Chang, Chao Wang, Meng Yan… in Nature Communications (2023)

Article

Clinical and biomarker analyses of sintilimab plus gemcitabine and cisplatin as first-line treatment for patients with advanced biliary tract cancer

The prognosis of biliary tract cancer (BTC) remains unsatisfactory. This single-arm, phase II clinical trial (ChiCTR2000036652) investigated the efficacy, safety, and predictive biomarkers of sintilimab plus g...

Tian-mei Zeng, Guang Yang, Cheng Lou, Wei Wei, Chen-jie Tao… in Nature Communications (2023)

Article

Cholesterol-stabilized membrane-active nanopores with anticancer activities

Cholesterol-enhanced pore formation is one evolutionary means cholesterol-free bacterial cells utilize to specifically target cholesterol-rich eukaryotic cells, thus esca** the toxicity these membrane-lytic ...

Jie Shen, Yongting Gu, Lingjie Ke, Qiu** Zhang, Yin Cao… in Nature Communications (2022)

Article

Retraction Note: Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells

Jiang-Qi Liu, **ng-Yong Li, Hai-Qiong Yu, Gui Yang, Zhi-Qiang Liu… in Scientific Reports (2021)

Article

A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against SARS-CoV-2 can provide an important treatment option to fight...

Yu Guo, Lisu Huang, Guangshun Zhang, Yanfeng Yao, He Zhou… in Nature Communications (2021)

Article

Physical activity, screen exposure and sleep among students during the pandemic of COVID-19

This study aimed to determine the levels of health-related behaviours (physical activity, screen exposure and sleep status) among Chinese students from primary, secondary and high schools during the pandemic o...

Yang-feng Guo, Min-qi Liao, Wei-li Cai, **ao-xuan Yu, Shu-na Li… in Scientific Reports (2021)

Article

RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

Growing evidences suggest that cancer stem cells exhibit many molecular characteristics and phenotypes similar to their ancestral progenitor cells. In the present study, human embryonic stem cells are induced ...

**a Wang, ** Wang, Yu-Man Tsui, Chaoran Shi, Ying Wang, **n Zhang… in Nature Communications (2021)

Article

The association between dietary fatty acid intake and the risk of develo** preeclampsia: a matched case–control study

The association between dietary fat intake during pregnancy and the risk of develo** preeclampsia has been examined in many epidemiological studies, but the results remain inconsistent. The aim of this study...

Shu-na Li, Yan-hua Liu, Ze-yan Luo, Yun-feng Cui, Yuan Cao… in Scientific Reports (2021)

Article

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms remain elusive. Through screening, we fou...

Jia Liu, Ze-**an Liu, Qi-Nian Wu, Yun-**n Lu, Chau-Wei Wong… in Nature Communications (2020)

Article

Prognostic model and optimal treatment for patients with stage IVc nasopharyngeal carcinoma at diagnosis

The treatment for patients with stage IVc nasopharyngeal carcinoma (NPC) at diagnosis was still controversial. In this study, we tried to build a prognostic score model and optimize the treatment for the patie...

Yun-ming Tian, Wei-zeng Huang, Yu-hong Lan, Chong Zhao, Li Bai… in Scientific Reports (2019)

Article

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

Defective ciliogenesis causes human developmental diseases termed ciliopathies. Microtubule (MT) asters originating from centrosomes in mitosis ensure the fidelity of cell division by positioning the spindle a...

Hai-Qing Tu, Xuan-He Qin, Zhi-Bin Liu, Zeng-Qing Song, Huai-Bin Hu… in Nature Communications (2018)

Article

Dietary magnesium deficiency impaired intestinal structural integrity in grass carp (Ctenopharyngodon idella)

Grass carp (223.85–757.33 g) were fed diets supplemented with magnesium (73.54–1054.53 mg/kg) for 60 days to explore the impacts of magnesium deficiency on the growth and intestinal structural integrity of the...

Shuo-Peng Wei, Wei-Dan Jiang, Pei Wu, Yang Liu, Yun-Yun Zeng… in Scientific Reports (2018)

Article

Automatic multiple zebrafish tracking based on improved HOG features

As an excellent model organism, zebrafish have been widely applied in many fields. The accurate identification and tracking of individuals are crucial for zebrafish shoaling behaviour analysis. However, multi-...

Yun-**ang Bai, Shu-Hui Zhang, Zhi Fan, **ng-Yu Liu, **n Zhao… in Scientific Reports (2018)

Article

SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis

Multiple Sclerosis (MS), is a chronic inflammatory autoimmune disorder of the central nervous system that leads to chronic demyelination with axonal damage and neuronal loss. Mesenchymal stem cells (MSCs) repr...

Yun-Liang Wang, Peng Xue, Chun-Yang Xu, Zhen Wang, **n-Shan Liu… in Scientific Reports (2018)