56 Result(s)
within
Yun-** Lim
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Formate-driven growth coupled with H2 production
The oxidation of formate to carbon dioxide and hydrogen is a common reaction in microorganisms in anaerobic environments, but it releases little energy and had not been shown to sustain growth in an isolated s...
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Article
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
If the full potential of human embryonic stem (ES) cells in research and clinical applications is to be realized, we need a detailed understanding of the genetic network that governs their unique properties. A...
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Article
DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel ...
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Article
Open AccessDesigning nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells
Inspired by ultrastructural analysis of ex vivo human tissues as well as the physiological importance of structural density, we fabricated nanogrooves with 1:1, 1:3 and 1:5 spacing ratio (width:spacing, width = 5...
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Article
Open AccessStability of Gut Enterotypes in Korean Monozygotic Twins and Their Association with Biomarkers and Diet
Studies on the human gut microbiota have suggested that human individuals could be categorized into enterotypes based on the compositions of their gut microbial communities. Here, we report that the gut microb...
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Article
Open AccessLatent progenitor cells as potential regulators for tympanic membrane regeneration
Tympanic membrane (TM) perforation, in particular chronic otitis media, is one of the most common clinical problems in the world and can present with sensorineural healing loss. Here, we explored an approach f...
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Article
Open AccessIdentification of disulfide cross-linked tau dimer responsible for tau propagation
Recent evidence suggests that tau aggregates are not only neurotoxic, but also propagate in neurons acting as a seed for native tau aggregation. Prion-like tau transmission is now considered as an important pa...
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Article
Open AccessComplete chloroplast and ribosomal sequences for 30 accessions elucidate evolution of Oryza AA genome species
Cytoplasmic chloroplast (cp) genomes and nuclear ribosomal DNA (nR) are the primary sequences used to understand plant diversity and evolution. We introduce a high-throughput method to simultaneously obtain co...
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Article
Open AccessRemarkably stable amorphous metal oxide grown on Zr-Cu-Be metallic glass
In the present study, we investigated the role of an aliovalent dopant upon stabilizing the amorphous oxide film. We added beryllium into the Zr50Cu50 metallic glass system and found that the amorphous oxide laye...
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Article
Open AccessAnkyrin Repeat Domain 1 is Up-regulated During Hepatitis C Virus Infection and Regulates Hepatitis C Virus Entry
Hepatitis C virus (HCV) is highly dependent on host proteins for its own propagation. By transcriptome sequencing (RNA-Seq) analysis, we identified 30 host genes that were significantly differentially expresse...
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Open AccessAnalysis of the association between host genetics, smoking, and sputum microbiota in healthy humans
Recent studies showing clear differences in the airway microbiota between healthy and diseased individuals shed light on the importance of the airway microbiota in health. Here, we report the associations of h...
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Article
Open AccessADP-ribosylation Factor-related Protein 1 Interacts with NS5A and Regulates Hepatitis C Virus Propagation
The life cycle of hepatitis C virus (HCV) is tightly coupled to the lipid metabolism of host cells. In order to identify host factors involved in HCV propagation, we have previously screened a small interferin...
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Article
Open AccessThe Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages
Prostate apoptosis response-4 (Par-4) is a tumor suppressor protein that forms a complex with glucose-regulated protein 78 (GRP78) to induce apoptosis. Previously, we reported that ER stress-induced apoptosis ...
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Article
Open AccessRoles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections
Alteration of macrophage function has an important regulatory impact on the survival of intracellular mycobacteria. We found that macrophages infected with attenuated Mycobacterium tuberculosis (Mtb) strain H37Ra...
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Article
Open AccessHepatitis C Virus Exploits Death Receptor 6-mediated Signaling Pathway to Facilitate Viral Propagation
The life cycle of hepatitis C virus (HCV) is highly dependent on host proteins for virus propagation. By transcriptome sequencing analysis, we identified host genes that were highly differentially expressed in...
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Article
Open AccessEffects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study
Clopidogrel is the mainstay for antiplatelet treatment after percutaneous coronary intervention (PCI). The relationship of platelet reactivity and genetic polymorphism with clinical outcomes with newer-generat...
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Article
Open AccessClinical and genomic landscape of gastric cancer with a mesenchymal phenotype
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP...
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Article
Open AccessAnti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice
15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Al...
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Article
Open AccessHepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation
Hepatitis C virus (HCV) exploits an extensive network of host proteins to maintain chronic infection. Using RNA-Seq technology, we identified 30 host genes that were differentially expressed in cell culture gr...
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Article
Open AccessMolecular architecture of a cylindrical self-assembly at human centrosomes
The cell is constructed by higher-order structures and organelles through complex interactions among distinct structural constituents. The centrosome is a membraneless organelle composed of two microtubule-der...
