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Article
Open AccessAntibody against apolipoprotein-A1, non-alcoholic fatty liver disease and cardiovascular risk: a translational study
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease increasing cardiovascular disease (CVD) morbidity and mortality. Autoantibodies against apolipoprotein A-1 (AAA-1) are a possible novel CVD r...
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Article
Open AccessPhosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinosit...
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Article
Open AccessHuman genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
Enterovirus 71 (EV71) is a neurotropic enterovirus without antivirals or vaccine, and its host-pathogen interactions remain poorly understood. Here we use a human genome-wide RNAi screen to identify 256 host f...
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Article
Open AccessScreenSifter: analysis and visualization of RNAi screening data
RNAi screening is a powerful method to study the genetics of intracellular processes in metazoans. Technically, the approach has been largely inspired by techniques and tools developed for compound screening, ...
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Article
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
If the full potential of human embryonic stem (ES) cells in research and clinical applications is to be realized, we need a detailed understanding of the genetic network that governs their unique properties. A...
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Article
An extract from the brown alga Bifurcaria bifurcata induces irreversible arrest of cell proliferation in a non-small-cell bronchopulmonary carcinoma line
In this study, the antiproliferative activity of a crude extract isolated from Bifurcaria bifurcata (Velley) Ross, a common marine brown alga of the Atlantic shores of Europe, was investigated. Its antiproliferat...
