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  1. Article

    Open Access

    Optimal immobilization position for conservative treatment of proximal humerus fractures by fracture type: a biomechanical cadaveric study

    In conservative treatment for proximal humerus fractures (PHFs), the immobilization position of the affected arm should not be determined uniformly. The aim of this study is to investigate the optimal immobili...

    Seokhwan **, Joon-Ryul Lim, Tae-Hwan Yoon, Yun-Rak Choi in Scientific Reports (2024)

  2. Article

    Open Access

    A natural product YSK-A blocks SARS-CoV-2 propagation by targeting multiple host genes

    Natural products and herbal medicine have been widely used in drug discovery for treating infectious diseases. Recent outbreak of COVID-19 requires various therapeutic strategies. Here, we used YSK-A, a mixtur...

    Thuy X. Pham, Trang T. X. Huynh, Bumseok Kim, Yun-Sook Lim in Scientific Reports (2023)

  3. Article

    Open Access

    Use of a point-of-care test to rapidly assess levels of SARS-CoV-2 nasal neutralising antibodies in vaccinees and breakthrough infected individuals

    Despite SARS-CoV-2 vaccines eliciting systemic neutralising antibodies (nAbs), breakthrough infections still regularly occur. Infection helps to generate mucosal immunity, possibly reducing disease transmissio...

    Chee Wah Tan, Chuan Kok Lim, Jacqueline Prestedge, Mitchell Batty in Scientific Reports (2023)

  4. Article

    Open Access

    Real-time dual prediction of intradialytic hypotension and hypertension using an explainable deep learning model

    Both intradialytic hypotension (IDH) and hypertension (IDHTN) are associated with poor outcomes in hemodialysis patients, but a model predicting dual outcomes in real-time has never been developed. Herein, we ...

    Donghwan Yun, Hyun-Lim Yang, Seong Geun Kim, Kwangsoo Kim in Scientific Reports (2023)

  5. Article

    Open Access

    Author Correction: Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons

    Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung ** Choi in Nature Communications (2023)

  6. Article

    Open Access

    Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons

    Small humanin-like peptide 2 (SHLP2) is a mitochondrial-derived peptide implicated in several biological processes such as aging and oxidative stress. However, its functional role in the regulation of energy h...

    Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung ** Choi in Nature Communications (2023)

  7. Article

    Open Access

    Machine-learning-based diagnosis of thyroid fine-needle aspiration biopsy synergistically by Papanicolaou staining and refractive index distribution

    We developed a machine learning algorithm (MLA) that can classify human thyroid cell clusters by exploiting both Papanicolaou staining and intrinsic refractive index (RI) as correlative imaging contrasts and e...

    Young Ki Lee, Dongmin Ryu, Seungwoo Kim, Juyeon Park, Seog Yun Park in Scientific Reports (2023)

  8. Article

    Open Access

    Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

    Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...

    Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo in Nature Communications (2023)

  9. Article

    Open Access

    Exercise with a wearable hip-assist robot improved physical function and walking efficiency in older adults

    Wearable assistive robotics has emerged as a promising technology to supplement or replace motor functions and to retrain people recovering from an injury or living with reduced mobility. We developed delayed ...

    Su-Hyun Lee, Jihye Kim, Bokman Lim, Hwang-Jae Lee, Yun-Hee Kim in Scientific Reports (2023)

  10. Article

    Open Access

    Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis

    Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation fa...

    Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau in Nature Communications (2023)

  11. Article

    Open Access

    Clinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome

    This study analyzed HGA and SFTS in patients with suspected tick-borne infection by focusing on key differences that clinicians can easily recognize. A retrospective analysis was performed on confirmed patient...

    Dong-Min Kim, Byung Jun Yu, Da Young Kim, Jun-Won Seo, Na-Ra Yun in Scientific Reports (2023)

  12. Article

    Open Access

    DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms

    Epigenetic influence plays a role in the association between exposure to air pollution and attention deficit hyperactivity disorder (ADHD); however, research regarding sulfur dioxide (SO2) is scarce. Herein, we i...

    Yoon-Jung Choi, **woo Cho, Yun-Chul Hong, Dong-wook Lee, Sungji Moon in Scientific Reports (2023)

  13. Article

    Open Access

    Correlates of burnout among healthcare workers during the COVID-19 pandemic in South Korea

    Burnout is a form of negative emotional and physical response to job stress. This study aimed to investigate the prevalence of burnout among healthcare workers responding to the coronavirus disease 2019 (COVID...

    Soyoon Hwang, Ki Tae Kwon, So Hee Lee, Shin-Woo Kim, Hyun-Ha Chang in Scientific Reports (2023)

  14. Article

    Open Access

    Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation

    Interleukin-9 (IL-9)-producing CD4+ T helper cells (Th9) have been implicated in allergy/asthma and anti-tumor immunity, yet molecular insights on their differentiation from activated T cells, driven by IL-4 and ...

    Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui in Nature Communications (2022)

  15. Article

    Open Access

    High low-density lipoprotein cholesterol level is associated with an increased risk of incident early-onset vasomotor symptoms

    We investigated the associations between serum lipid profiles and risk of early-onset vasomotor symptoms (VMSs) in premenopausal women. This cohort study comprised 2,540 premenopausal women aged 42–52 years wi...

    Hye Rin Choi, Yoosoo Chang, Ye** Kim, Jeonggyu Kang, Min-Jung Kwon in Scientific Reports (2022)

  16. Article

    Open Access

    Toxoplasma gondii and Rickettsia spp. in ticks collected from migratory birds in the Republic of Korea

    Migratory birds disperse ticks and associated tick-borne pathogens along their migratory routes. Four selected pathogens of medical importance (Coxiella burnetii, Rickettsia spp., Francisella tularensis, and Toxo...

    A.-Tai Truong, Mi-Sun Yoo, Subin Min, Ji-Yeon Lim, Hyun-Ji Seo in Scientific Reports (2022)

  17. Article

    Open Access

    Low anti-Müllerian hormone levels are associated with an increased risk of incident early-onset vasomotor symptoms among premenopausal women

    The role of anti-Müllerian hormone (AMH) levels in incident vasomotor symptoms (VMS) is largely unknown. This study aimed to investigate the relationship between AMH levels and the development of early-onset V...

    SunJu NamGoung, Yoosoo Chang, Ye** Kim, Hoon Kim, In Young Cho in Scientific Reports (2022)

  18. Article

    Open Access

    Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis

    Phthalates are well-known endocrine-disrupting chemicals. Many detrimental health effects of phthalates were investigated, but studies on the association of phthalates with obesity in children showed inconsist...

    Dong-Wook Lee, Hyun-Mook Lim, Joong-Yub Lee, Kyung-Bok Min in Scientific Reports (2022)

  19. Article

    Open Access

    Author Correction: Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

    Sung-Il Yun, Sang-Kyu Lee, Eun-Ah Goh, Oh Seung Kwon, Woorim Choi in Scientific Reports (2022)

  20. Article

    Open Access

    Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

    Androgenetic alopecia (AGA) is the most common type of hair loss in men and women. Dihydrotestosterone (DHT) and androgen receptor (AR) levels are increased in patients with AGA, and DHT-AR signaling correlate...

    Sung-Il Yun, Sang-Kyu Lee, Eun-Ah Goh, Oh Seung Kwon, Woorim Choi in Scientific Reports (2022)

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