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  1. Article

    Open Access

    A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1

    Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is an autoinhibitory NAD-consuming enzyme that is activated by the accumulation of nicotinamide mononucleotide (NMN) during ...

    Yun Nan Hou, Yang Cai, Wan Hua Li, Wei Ming He, Zhi Ying Zhao… in Nature Communications (2022)

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  2. No Access

    Article

    ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053

    Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody therapeutics (e.g., daratumumab) targeting...

    Cheng Wang, Yumei Chen, Yun Nan Hou… in European Journal of Nuclear Medicine and M… (2021)

  3. Article

    Open Access

    Immuno-targeting the multifunctional CD38 using nanobody

    CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including multiple myeloma (MM) and has been proven to be a good target for immunotherapy of the disease. CD38 is also a ...

    Ting Li, Shali Qi, Mandy Unger, Yun Nan Hou, Qi Wen Deng, Jun Liu… in Scientific Reports (2016)

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