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Article
Open AccessA conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1
Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is an autoinhibitory NAD-consuming enzyme that is activated by the accumulation of nicotinamide mononucleotide (NMN) during ...
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Article
ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053
Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody therapeutics (e.g., daratumumab) targeting...
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Article
Open AccessImmuno-targeting the multifunctional CD38 using nanobody
CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including multiple myeloma (MM) and has been proven to be a good target for immunotherapy of the disease. CD38 is also a ...