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  1. No Access

    Article

    PDIA2 has a dual function in promoting androgen deprivation therapy induced venous thrombosis events and castrate resistant prostate cancer progression

    Androgen deprivation therapy (ADT) is the first line of treatment for metastatic prostate cancer (PCa) that effectively delays the tumor progression. However, it also increases the risk of venous thrombosis ev...

    Yinan Li, Lei Lv, Meng Ye, Ning **e, Ladan Fazli, Yuli Wang, Weilun Wang… in Oncogene (2024)

  2. Article

    Open Access

    m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop

    Pancreatic cancer (PC) is the most hypoxic cancer type among solid tumors. The dynamic changes of RNA N6-methyl-adenosine (m6A) contribute to tumor cells adaption to hypoxic microenvironmental. However, the re...

    **aoyan Liu, Maoxiao Feng, **aodong Hao, Zihan Gao, Zhaoxin Wu, Yuli Wang… in Oncogene (2023)

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  3. Article

    Open Access

    FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression

    As a classically known mitogen, fibroblast growth factor 1 (FGF1) has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection. Here, we show that serum levels of ...

    Dezhong Wang, Yuan Yin, Shuyi Wang… in Signal Transduction and Targeted Therapy (2021)

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  4. No Access

    Article

    Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer

    Tumor-associated macrophages (TAMs) are the most abundant cancer stromal cells and play an essential role in tumor immunosuppression, providing a suitable microenvironment for cancer development and progressio...

    Lisha Zhou, Yanyu Jiang, **aojun Liu, Lihui Li, Xuguang Yang, Changsheng Dong… in Oncogene (2019)

  5. No Access

    Article

    BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers

    Breast cancer gene 1 (BRCA1) mutations predispose women to breast and ovarian cancers and men to increased risks for prostate cancer. We have previously showed BRCA1 splice variant BRCA1a/p110 to induce apopto...

    C Yuli, N Shao, R Rao, P Aysola, V Reddy, G Oprea-llies, L Lee, J Okoli… in Oncogene (2007)

  6. No Access

    Article

    LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma

    We have previously identified several novel genes, which are differentially expressed among human normal liver and hepatocellular carcinomas (HCCs). The full-length liver fibrinogen-related gene-1 (LFIRE-1) cDNA ...

    Jun Yan, Yanlin Yu, Nan Wang, Yunchao Chang, Hao Ying, Weizhong Liu, ** He… in Oncogene (2004)

  7. No Access

    Article

    c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells

    Elk-1, a c-Fos protooncogene regulator, which belongs to the ETS-domain family of transcriptional factors, plays an important role in the induction of immediate early gene expression in response to a variety o...

    YuLi Chai, Galina Chipitsyna, Jianqi Cui, Boshan Liao, Shuang Liu… in Oncogene (2001)

  8. No Access

    Article

    The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter

    Inherited mutations in the breast and ovarian cancer susceptibility gene BRCA1 are associated with high risk for develo** breast and ovarian cancers. Several studies link BRCA1 to transcriptional regulation,...

    YuLi Chai, Jian-qi Cui, Ningsheng Shao, E Shyam P Reddy, Veena N Rao in Oncogene (1999)

  9. No Access

    Article

    Induction of apoptosis by Elk-1 and ΔElk-1 proteins

    Elk-1, an ets related gene codes for at least two splice variants Elk-1, which regulates c-fos transcription and ΔElk-1, both of which function as transcriptional activators. To investigate the role of Elk-1 and ...

    Ningsheng Shao, YuLi Chai, Jian-qi Cui, Nan Wang, Kartik Aysola… in Oncogene (1998)

  10. No Access

    Article

    Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound

    p53, a tumor suppressor gene, functioning as a transcription factor, has been recently shown in a cell free system to be subject to redox (reduction/oxidation) regulation. Oxidants or metal chelating reagents ...

    Yi Sun, Junhui Bian, Yuli Wang, Christine Jacobs in Oncogene (1997)