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  1. No Access

    Article

    Safety and efficacy of administering the maximal dose of candesartan in renal transplant recipients

    The regular dose of an angiotensin II type-1 receptor blocker (ARB) in renal transplant patients for hypertension is shown to be safe and effective; however, information on the appropriate dosing of ARBs in re...

    Masayoshi Okumi, Noritaka Kawada, Naotsugu Ichimaru… in Clinical and Experimental Nephrology (2011)

  2. No Access

    Article

    Negative effects of anemia on quality of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients

    Anemia is a common complication in posttransplant patients (posttransplant anemia: PTA). We tested the hypothesis that targeting hemoglobin (Hb) over 13.3 g/dl by administration of recombinant human erythropoi...

    Noritaka Kawada, Toshiki Moriyama… in Clinical and Experimental Nephrology (2009)

  3. No Access

    Article

    Correlation between the Banff 97 classification of renal allograft biopsies and clinical outcome

    The 1997 fourth Banff meeting revised the consensus for describing transplant biopsies. We have conducted a retrospective analysis of biopsies correlated between the Banff 97 classification and clinical outcom...

    Toshiyuki Tanaka, Masahiro Kyo, Yukito Kokado, Shiro Takahara… in Transplant International (2004)

  4. No Access

    Article

    Differences in binding of glucocorticoid receptor to DNA in chronic renal graft rejection

    Although chronic rejection is the most common reason for late allograft loss, its pathophysiology and etiology are unclear. Attempts to prevent chronic rejection are now focused on the modulation of transcrip...

    Naotsugu Ichimaru, S. Takahara, **g-Ding Wang, Norio Nonomura… in Transplant International (2000)

  5. No Access

    Article

    Factors influencing vertebral bone density after renal transplantation

    To improve our understanding of the mechanisms underlying osteoporosis following renal transplantation, we compared bone mineral density (BMD) in 158 transplant recipients and in 293 patients undergoing maint...

    Yukito Kokado, Shirou Takahara, Naotugu Ichimaru, Kiyohide Toki… in Transplant International (2000)

  6. No Access

    Article

    Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats

    Renal toxicity is a serious side effect of therapy with tacrolimus (FK506), an immunosuppressive agent administered to renal transplant recipients. We investigated the effect of hepatocyte growth factor (HGF)...

    Shingo Takada, Shiro Takahara, Kenji Nishimura… in Transplant International (1999)

  7. No Access

    Article

    Morphological findings in non-episode biopsies of kidney transplant allografts treated with FK506 or cyclosporine

    We conducted an analysis of biopsy specimens of non-episode renal allografts from patients treated with tacrolimus (FK506) or cyclosporine (CsA) to evaluate chronic drug-induced nephropathy in stable allograf...

    M. Kyo, Motoaki Hatori, Shiro Takahara, Miyaji Kyakuno… in Transplant International (1998)

  8. No Access

    Article

    A comparative study of FK506 granules and capsules in renal transplant recipients

    Nine renal transplant recipients in stable systemic condition on FK506 capsules were converted to FK506 granules in order to investigate the safety, efficacy, and pharmacokinetics of the granular formulation ...

    S. Takahara, Tsuneharu Miki, Motoaki Hatori, Yukito Kokado… in Transplant International (1998)

  9. No Access

    Article

    Serum HGF levels in acute renal rejection after living related renal transplantation

    Hepatocyte growth factor (HGF), a long sought-after hepatotrophic factor, has recently been shown to act as a renotrophic factor in regeneration of the kidney. We investigated serum HGF levels in 16 renal tran...

    Shingo Takada, Mikio Namiki, Shiro Takahara, Kiyomi Matsumiya… in Transplant International (1996)

  10. No Access

    Article

    In vivo and in vitro mechanisms of cardiac allograft acceptance in the rat after short treatment with 15-deoxyspergualin

    15-Deoxyspergualin (DSG) has been reported to be a useful immunosuppressive agent already used to inhibit acute rejection in clinical transplantation. In the present study, the survival of heart allograft in r...

    Hongsi Jiang, Shiro Takahara, Masahiro Kyo, Yuji Takano… in Transplant International (1992)