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  1. Article

    Open Access

    HLA-DRB1*04:05 is involved in the development of Vogt–Koyanagi–Harada disease-like immune-related adverse events in patients receiving immune checkpoint inhibitors

    Immune checkpoint inhibitors (ICIs) activate anti-tumor activity by inhibiting immune checkpoint molecules that suppress inflammatory T-cell activity. However, ICIs can initiate excessive immune responses, the...

    Masaki Takeuchi, Akira Meguro, Jutaro Nakamura, Rei Chikagawa in Scientific Reports (2023)

  2. Article

    Open Access

    Blood and lymphatic systems are segregated by the FLCN tumor suppressor

    Blood and lymphatic vessels structurally bear a strong resemblance but never share a lumen, thus maintaining their distinct functions. Although lymphatic vessels initially arise from embryonic veins, the molec...

    Ikue Tai-Nagara, Yukiko Hasumi, Dai Kusumoto, Hisashi Hasumi in Nature Communications (2020)