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  1. Article

    Open Access

    HLA-DRB1*04:05 is involved in the development of Vogt–Koyanagi–Harada disease-like immune-related adverse events in patients receiving immune checkpoint inhibitors

    Immune checkpoint inhibitors (ICIs) activate anti-tumor activity by inhibiting immune checkpoint molecules that suppress inflammatory T-cell activity. However, ICIs can initiate excessive immune responses, the...

    Masaki Takeuchi, Akira Meguro, Jutaro Nakamura, Rei Chikagawa… in Scientific Reports (2023)

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  2. No Access

    Article

    An open-label, prospective, single-arm study of switching from infliximab to cyclosporine for refractory uveitis in patients with Behçet’s disease in long-term remission

    Although infliximab (IFX) decreases the risk of blindness due to refractory uveitis in patients with Behçet's disease (BD), there are no standard criteria for IFX switching or withdrawal. To evaluate the effec...

    Yasutsugu Ida, Masaki Takeuchi, Mami Ishihara… in Japanese Journal of Ophthalmology (2021)

  3. Article

    Open Access

    Blood and lymphatic systems are segregated by the FLCN tumor suppressor

    Blood and lymphatic vessels structurally bear a strong resemblance but never share a lumen, thus maintaining their distinct functions. Although lymphatic vessels initially arise from embryonic veins, the molec...

    Ikue Tai-Nagara, Yukiko Hasumi, Dai Kusumoto, Hisashi Hasumi… in Nature Communications (2020)

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  4. No Access

    Article

    Analysis of single nucleotide polymorphisms at 13 loci within the transforming growth factor-induced factor gene shows no association with high myopia in Japanese subjects

    A previous study in China first indicated that the transforming growth factor-induced factor (TGIF) is a probable candidate gene for high myopia. The purpose of our study was to investigate whether there are sign...

    Yukiko Hasumi, Hidetoshi Inoko, Shuhei Mano, Masao Ota, Eiichi Okada… in Immunogenetics (2006)