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Article
ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3β/β-catenin pathway
Osteophyte development is a common characteristic of inflammatory skeletal diseases. Elevated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) participates in pathological osteogenesis....
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Article
Open AccessClinical characteristics and risk factors associated with bone erosion in patients with tophi
If a large amount of urate crystals is deposited in a joint cavity for an extended period of time, bone erosion will occur and gradually cause skeletal muscle necrosis and joint deformity. The aim of this stud...
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Article
Improved Prediction of Knee Osteoarthritis by the Machine Learning Model XGBoost
The accurate prediction of osteoarthritis (OA) severity in patients can be helpful to make the proper decision of intervention. This study aims to build up a powerful model to assess predictive risk factors an...
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Article
Open AccessRevolutionizing viral disease vaccination: the promising clinical advancements of non-replicating mRNA vaccines
The mRNA vaccine technology was developed rapidly during the global pandemic of COVID-19. The crucial role of the COVID-19 mRNA vaccine in preventing viral infection also have been beneficial to the exploratio...
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Article
Analysis and Design of a High-Bandwidth Front-End Sampler for Time-Interleaved ADCs
This paper analyzes high-speed front-end samplers and presents a 1 × 4 × 8 three-stage sampler for time-interleaved analog-to-digital converters. The front-end sampler mitigates timing skew and extends bandwid...
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Article
Open AccessRealizing the full reservoir operation potential during the 2020 Yangtze river floods
Five severe floods occurred in the Yangtze River Basin, China, between July and August 2020, and the Three Gorges Reservoir (TGR) located in the middle Yangtze River experienced the highest inflow since constr...
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Article
Open AccessImplementation of telemedicine for knee osteoarthritis: study protocol for a randomized controlled trial
Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular ...
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Article
Immunomodulatory effects of mesenchymal stromal cells-derived exosome
The mechanisms underlying immunomodulatory ability of mesenchymal stromal cells (MSCs) remain unknown. Recently, studies suggested that the immunomodulatory activity of MSCs is largely mediated by paracrine fa...
