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    Chapter

    Crossing the Blood-Brain Barrier with AAVs: What’s After SMA?

    The 2009 discovery that the AAV9 serotype can deliver genes across the blood-brain barrier (BBB) spurred the rapid development of a recently FDA-approved gene therapy for spinal muscular atrophy (SMA). The suc...

    Yujia Alina Chan, Benjamin E. Deverman in Drug Delivery to the Brain (2022)

  2. Article

    Open Access

    Systematic auditing is essential to debiasing machine learning in biology

    Biases in data used to train machine learning (ML) models can inflate their prediction performance and confound our understanding of how and what they learn. Although biases are common in biological data, syst...

    Fatma-Elzahraa Eid, Haitham A. Elmarakeby, Yujia Alina Chan in Communications Biology (2021)