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Article
Open AccessAn atlas of substrate specificities for the human serine/threonine kinome
Protein phosphorylation is one of the most widespread post-translational modifications in biology1,2. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylati...
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Article
Open AccessAuthor Correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessHigh-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS ...
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Article
Architecture of the Mediator head module
The Mediator complex is a large molecular machine linking transcriptional activators and repressors to RNA polymerase II. It contains three subcomplexes, one of which is a seven-subunit head module. Imasaki et al
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Article
Mediator Head module structure and functional interactions
By controlling interaction with RNA polymerase II, the Head module portion of Mediator plays a critical role in transcriptional regulation. A study now characterizes different conformations of the Head and als...
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Article
Successful Treatment of Massive Bleeding into the Open Thoracotomy Space by Pulmonary Artery Occlusion: Report of a Case
A 69-year-old man underwent decortication and latissimus dorsi muscle transposition for the treatment of chronic empyema in January 2001. The empyema recurred in March 2002, and open drainage was thus started ...
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Article
A comparison of video and digital data in the assessment of myocardial perfusion abnormalities by myocardial contrast echocardiography
Objective: The objective of the present study was to compare the digital and video data of myocardial contrast echocardiography (MCE) to assess altered myocardial blood flow produced by graded coronary stenoses....
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Article
Potential pitfalls of visualization of myocardial perfusion by myocardial contrast echocardiography with harmonic gray scale B-mode and power Doppler imaging
Objective: The present study compared the regional variation of myocardial signal intensity in visualizing myocardial perfusion by myocardial contrast echocardiography (MCE) between harmonic gray scale and power...
