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Article
Open AccessCorrection: Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
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Article
Open AccessStatus of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Glioblastoma multiforme (GBM) acquires resistance to bevacizumab (Bev) treatment. Bev affects angiogenic factors other than vascular endothelial growth factor (VEGF), which are poorly understood. We investigat...
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Article
Open AccessAn exploratory prospective phase II study of preoperative neoadjuvant bevacizumab and temozolomide for newly diagnosed glioblastoma
This multi-institutional phase I/II study was conducted to confirm the safety and explore the clinical utility of preoperative Bevacizumab (Bev) for newly diagnosed glioblastoma (GB).
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Article
Open AccessPrognostic survival biomarkers of tumor-fused dendritic cell vaccine therapy in patients with newly diagnosed glioblastoma
Dendritic cell (DC)-based immunotherapy has been applied to glioblastoma (GBM); however, biomarkers informing response remain poorly understood. We conducted a phase I/IIa clinical trial investigating tumor-fu...
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Article
Multimodal treatment including lumbar facet joint denervation for severe low back pain in patients with neuromuscular disorders
Severe low back pain (LBP) is an occasional complaint in patients with neuromuscular disorders (NMDs). Accurate diagnosis and treatment are required to manage LBP; however, the precise pathophysiology differs ...
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Article
Communication-type smartphone application can contribute to reducing elapsed time to reperfusion therapy
Communication-type medical smartphone applications enable text, neuroimaging, photos, and videos to be shared securely among the stroke team. Our aim was to investigate whether use of a smartphone application ...
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Article
Thoracic and lumbar spine pedicle morphology in Japanese patients
Pedicle morphology is important for intraoperative surgical anatomy and to define pedicle screw design and parameters. However, differences of pedicle size according to ethnicity and gender are not well studie...
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Article
MRI characteristics of syringomyelia associated with foramen magnum arachnoiditis: differentiation from Chiari malformation
It is important to distinguish foramen magnum arachnoiditis (FMA) from Chiari malformation (CM) before surgery because the operative strategies for these diseases differ. In the current study, we compared pret...
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Article
Open AccessClinical predictors of surgical outcomes of severe carpal tunnel syndrome patients: utility of palmar stimulation in a nerve conduction study
Carpal tunnel syndrome is a common peripheral nerve compression disorder. However, there is no established opinion regarding the predictors of symptom improvement after surgery. This study aimed to identify th...
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Article
Open AccessThe role of vascular endothelial growth factor in the hypoxic and immunosuppressive tumor microenvironment: perspectives for therapeutic implications
The microvasculature and immune cells are major components of the tumor microenvironment (TME). Hypoxia plays a pivotal role in the TME through hypoxia-inducible factor 1-alpha (HIF-1α) which upregulates vascu...
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Article
Open AccessAccuracy of Length of Virtual Stents in Treatment of Intracranial Wide-Necked Aneurysms
Precise stent deployment is important for successful treatment of intracranial aneurysms by stent-assisted coiling (SAC). We evaluated the accuracy of virtual stents generated using commercial stent planning s...
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Article
Common Data Elements for Subarachnoid Hemorrhage and Unruptured Intracranial Aneurysms: Recommendations from the Working Group on Subject Characteristics
The National Institute of Neurological Disorders and Stroke (NINDS) Common Data Elements (CDEs) have been generated to standardize and define terms used by the scientific community. The widespread use of these...
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Article
Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma
This trial was designed to evaluate the safety and clinical responses to a combination of temozolomide (TMZ) chemotherapy and immunotherapy with fusions of DCs and glioma cells in patients with glioblastoma (G...
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Article
Open AccessEmergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE
The H-type of atypical bovine spongiform encephalopathy (H-BSE) was serially passaged in bovinized transgenic (TgBoPrP) mice. At the fourth passage, most challenged mice showed a typical H-BSE phenotype with i...
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Article
BRAF V600E-mutated diffuse glioma in an adult patient: a case report and review
Recent advances in genomic technology and genome-wide analysis have identified key molecular alterations that are relevant to the diagnosis and prognosis of brain tumors. Molecular information such as mutation...
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Article
Open AccessRapid assessment of bovine spongiform encephalopathy prion inactivation by heat treatment in yellow grease produced in the industrial manufacturing process of meat and bone meals
Prions, infectious agents associated with transmissible spongiform encephalopathy, are primarily composed of the misfolded and pathogenic form (PrPSc) of the host-encoded prion protein. Because PrPSc retains infe...
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Article
Incidence and neurological outcomes of aneurysm rupture during interventional neuroradiology procedures in a hybrid operating suite
A hybrid operating suite, where craniotomy, brain CT scanning, fluoroscopy, and angiography can be performed on the same operating table, is becoming popular among neurosurgeons. However, whether use of a hybr...
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Article
Open AccessIntravascular tissue reactions induced by various types of bioabsorbable polymeric materials: correlation between the degradation profiles and corresponding tissue reactions
Several different bioabsorbable polymeric coil materials are currently used with the goal of improving treatment outcomes of endovascular embolization of intracranial aneurysms. However, little is known about ...
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Chapter
Topic 1: Behavior-Related Candidate Genes in Japanese Macaques
In Japanese macaques, records of individual behavior and regional differences have been accumulated by long-term observations and are suitable for the analysis of an inherited factor in the background. In huma...
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Article
Allele distribution and effect on reporter gene expression of vasopressin receptor gene (AVPR1a)-linked VNTR in primates
We surveyed repeat sequence in the 5′ flanking region of primate arginine vasopressin receptor 1a gene (AVPR1a) which is important for social behavior in mammals. The amplified region was polymorphic in length in...
