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Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a br...
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Preparation and Evaluation of Rationally Designed Polymers for Efficient Endosomal Escape of siRNA
Small interfering RNA (siRNA) showed promising prospect in the fields of basic research and drug development due to its capability in inhibition of the expression of any interest gene. However, delivery is the...
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Advances in mRNA Delivery and Clinical Applications
Messenger RNA (mRNA) as a naturally occurring molecule is involved in the transmission of genetic information. It has shown great potential in field of vaccination, protein-replacement therapy, and treatment o...
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Preparation and Evaluation of Rationally Designed Polymers for Efficient Endosomal Escape of siRNA
Small interfering RNA (siRNA) showed promising prospect in the fields of basic research and drug development due to its capability in inhibition of the expression of any interest gene. However, delivery is the...
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Open AccessThe microgravity enhanced polymer-mediated siRNA gene silence by improving cellular uptake
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Open AccessTherapeutic siRNA: state of the art
RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequence-specific manner, making small interferi...
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The Advances of Biomacromolecule-based Nanomedicine in Brain Disease
Brain diseases affect a sizable portion of people in the world. Various treatment modalities have been pursued to control, alleviate, or cure these disorders. Biomacromolecules, e.g., antibody, peptide, enzyme...
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A covalently crosslinked polysaccharide hydrogel for potential applications in drug delivery and tissue engineering
The development of non-cytotoxic hydrogels that can allow for the controlled release of molecules has important clinical and therapeutic applications. In this paper, we developed a series of in situ hydrogels ...
