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Open AccessBroadening bandgaps in a multi-resonant piezoelectric metamaterial plate via bandgap merging phenomena
Locally resonant metamaterials usually have narrow bandgaps, which significantly limits their applications in realistic engineering environments. In this paper, an optimization method based on the genetic algo...
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Article
Open AccessHigh-efficiency dysprosium-ion extraction enabled by a biomimetic nanofluidic channel
Biological ion channels exhibit high selectivity and permeability of ions because of their asymmetrical pore structures and surface chemistries. Here, we demonstrate a biomimetic nanofluidic channel (BNC) with...
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Article
Open AccessInfluencing on police-community relations: an empirical study based on the OIC three-dimensional model
The
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Open AccessElevated SLC3A2 associated with poor prognosis and enhanced malignancy in gliomas
The role of SLC3A2, a gene implicated in disulfidptosis, has not been characterized in gliomas. This study aims to clarify the prognostic value of SLC3A2 and its influence on glioma. We evaluated the expressio...
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Open AccessAssociation between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients
The management of preoperative blood glucose levels in reducing the incidence of postoperative delirium (POD) remains controversial. This study aims to investigate the impact of preoperative persistent hypergl...
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Article
Open AccessSETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
Transposable elements play a critical role in maintaining genome architecture during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of transposable elements, are known to harbor...
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Article
Open AccessC8-ceramide modulates microglia BDNF expression to alleviate postoperative cognition dysfunction via PKCδ/NF-κB signaling pathway
Postoperative cognitive dysfunction (POCD) is a kind of serious postoperative complication in surgery with general anesthesia and it may affect patients’ normal lives. Activated microglia are thought to be one...
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Article
Open AccessKnowledge Graph-Aware Deep Interest Extraction Network on Sequential Recommendation
Sequential recommendation is the mainstream approach in the field of click-through-rate (CTR) prediction for modeling users’ behavior. This behavior implies the change of the user’s interest, and the goal of s...
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Article
Open AccessSystematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition
The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected during z...
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Open AccessEfficacy and safety of drug-coated balloons in chronic total coronary occlusion recanalization: a systematic review and meta-analysis
With advancements in chronic total coronary occlusion (CTO) recanalization techniques and concepts, the success rate of recanalization has been steadily increasing. However, the current data are too limited to...
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Article
Open AccessEnhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by mitochondrial dysfunction and accumulation of alpha-synuclein (α-Syn)-containing protein aggregates known as Lewy bodies (LB...
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Article
Open AccessGliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction
To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular a...
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Open AccessComparison of intravascular lithotripsy versus rotational atherectomy for the treatment of severe coronary artery calcification
Calcified lesions are one of the most challenging cases for PCI, where optimal angiographic results and satisfying outcomes are hard to achieve.
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Open AccessAnti-CD5 CAR-T cells with a tEGFR safety switch exhibit potent toxicity control
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Open AccessAdvances in nanomaterial-targeted treatment of acute lung injury after burns
To summarize the mechanisms and pathophysiological features of ALI after burn.
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Open AccessMediating effect of adiponectin between free fatty acid and tumor necrosis factor-α in patients with diabetes
Increased free fatty acid (FFA) promotes adiponectin secretion in healthy subjects and induces inflammation in diabetes. Given the potential pro-inflammatory role of adiponectin in “adiponectin paradox”, we pe...
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Article
Open AccessThe relationship between sleep disturbance and aggressive behaviour among community-dwelling schizophrenia patients: a moderated mesomeric effect model
Sleep disturbance is the most common concern of patients with schizophrenia and can lead to a poor prognosis, a low survival rate and aggressive behaviour, posing a significant threat to social security and st...
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Article
Open AccessFoldPAthreader: predicting protein folding pathway using a novel folding force field model derived from known protein universe
Protein folding has become a tractable problem with the significant advances in deep learning-driven protein structure prediction. Here we propose FoldPAthreader, a protein folding pathway prediction method th...
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Article
Open AccessComparative study of good governance on poverty reduction in Rwanda and Burundi
The framework of good governance, popular in the 1980s and 1990s, is considered to be one of the effective weapons of development in Africa. However, its performance has been considered uneven and itself has b...
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Article
Open AccessSignaling pathways in colorectal cancer: implications for the target therapies
Colorectal carcinoma (CRC) stands as a pressing global health issue, marked by the unbridled proliferation of immature cells influenced by multifaceted internal and external factors. Numerous studies have expl...
