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Article
Open AccessLarge-scale networks changes in Wilson’s disease associated with neuropsychiatric impairments: a resting-state functional magnetic resonance imaging study
In Wilson’s disease (WD) patients, network connections across the brain are disrupted, affecting multidomain function. However, the details of this neuropathophysiological mechanism remain unclear due to the r...
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Article
Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion
To improve the efficacy of lenvatinib in combination with programmed death-1 (PD-1) blockade therapy for hepatocellular carcinoma (HCC), we screened the suppressive metabolic enzymes that sensitize HCC to lenv...
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Article
Open AccessLysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase
To overcome chemotherapy resistance, novel strategies sensitizing cancer cells to chemotherapy are required. Here, we screen the lysyl-oxidase (LOX) family to clarify its contribution to chemotherapy resistanc...
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Article
Open AccessReading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice
N6-methyladenosine (m6A) modification has been shown to regulate RNA metabolism. Here, we investigate m6A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show...
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Article
Effective shape-controlled synthesis of gallium selenide nanosheets by vapor phase deposition
The controlled synthesis of large and uniform gallium selenide (GaSe) crystals is crucial for its various applications based on the attractive properties of this emerging material. In this work, vapor phase gr...
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Article
Microstructure and UV Fluorescence of Amorphous I/Au Composite Nanofilms Based on LVDCS Method
The amorphous I/Au composite nanoflms were prepared by low vacuum direct current sputtering (LVDCS) method. The optimized preparation technologies contain growth pressure, time, gaseous environment and anneali...
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Article
Open AccessThe availability, price and affordability of essential antibacterials in Hubei province, China
China ranks first amongst the countries for the abuse of antibacterials. Essential antibacterials could help solve the problem. The aim of the work is to evaluate the availability, price and affordability of e...
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Article
Open AccessHigh-fat diet and chronic stress aggravate adrenal function abnormality induced by prenatal caffeine exposure in male offspring rats
We previously demonstrated thatprenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted in developmental programming changes in offspring rats. However, whether these changes play...
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Chapter and Conference Paper
Resource Sharing Technology in the Automobile Parts Manufacture Grid
The manufacture resource classification model is described by using UML class graph in the manufacture grid system of automobile parts industry. Manufacture grid service system structure and resource agent str...
