19 Result(s)

Article

Molecular basis of Mg²⁺ permeation through the human mitochondrial Mrs2 channel

Mitochondrial RNA splicing 2 (Mrs2), a eukaryotic CorA ortholog, enables Mg²⁺ to permeate the inner mitochondrial membrane and plays an important role in mitochondrial metabolic function. However, the mechanism b...

Ming Li, Yang Li, Yue Lu, Jianhui Li, Xuhang Lu, Yue Ren… in Nature Communications (2023)

Article

Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers

Store-operated calcium entry (SOCE) is a major pathway for calcium ions influx into cells and has a critical role in various cell functions. Here we demonstrate that calcium-bound calmodulin (Ca²⁺-CaM) binds to t...

**n Li, Guangyan Wu, Yin Yang, Shijuan Fu, **aofen Liu… in Nature Communications (2017)

Article

Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex

Jianrong Feng, Shijuan Fu, Xuan Cao, Hao Wu, **g Lu, Ming Zeng, Lin Liu… in Protein & Cell (2017)

Article

Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca²⁺/H⁺ antiporter

Leucine zipper-EF-hand-containing transmembrane protein1 (LETM1) is located in the mitochondrial inner membrane and is defective in Wolf-Hirschhorn syndrome. LETM1 contains only one transmembrane helix, but it...

Juan Shao, Zhenglin Fu, Yanli Ji, **angchen Guan, Shang Guo… in Scientific Reports (2016)

Article

CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence

Calcium signaling plays an essential role in plant cell physiology, and chaperone-mediated protein folding directly regulates plant programmed cell death. The Arabidopsis thaliana protein AtBAG5 (Bcl-2-associated...

Luhua Li, Yangfei **ng, Dong Chang, Shasha Fang, Boyang Cui, Qi Li… in Scientific Reports (2016)

Article

The structure of WbnH in a near active state

Fengzhi Li, Siwei Li, **aofen Liu, Xue Yang, Peng Wang, Yuequan Shen in Protein & Cell (2015)

Article

Inside-out Ca²⁺ signalling prompted by STIM1 conformational switch

Store-operated Ca²⁺ entry mediated by STIM1 and ORAI1 constitutes one of the major Ca²⁺ entry routes in mammalian cells. The molecular choreography of STIM1–ORAI1 coupling is initiated by endoplasmic reticulum (E...

Guolin Ma, Ming Wei, Lian He, Chongxu Liu, Bo Wu… in Nature Communications (2015)

Article

Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4^DCAF1. Numerous mutations of Merlin have been identified in ...

Youjun Li, Hao Zhou, Fengzhi Li, Siew Wee Chan, Zhijie Lin, Zhiyi Wei… in Cell Research (2015)

Article

Auto-inhibitory Mechanism of the Human Mitochondrial RNase P Protein Complex

It is known that tRNAs play an essential role in genetic information transfer from DNA to protein. The maturation of tRNA precursors is performed by the endoribonuclease RNase P, which classically consists of ...

Fengzhi Li, **aofen Liu, Weihong Zhou, Xue Yang, Yuequan Shen in Scientific Reports (2015)

Article

Structural Insight into the Central Element Assembly of the Synaptonemal Complex

The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a cry...

**g Lu, Yanling Gu, Jianrong Feng, Weihong Zhou, Xue Yang… in Scientific Reports (2014)

Article

Structure of the kinase domain of human RNA-dependent protein kinase with K296R mutation reveals a face-to-face dimer

RNA-dependent protein kinase (PKR) is crucial for the innate immune response, cell growth, proliferation, signal transduction and apoptosis. The activation process of PKR has been studied for many years and is...

FengZhi Li, SiWei Li, Zheng Wang, YueQuan Shen, TongCun Zhang… in Chinese Science Bulletin (2013)

Article

Structural insight into substrate specificity of human intestinal maltase-glucoamylase

Human maltase-glucoamylase (MGAM) hydrolyzes linear alpha-1,4-linked oligosaccharide substrates, playing a crucial role in the production of glucose in the human lumen and acting as an efficient drug target fo...

Limei Ren, **aohong Qin, **aofang Cao, Lele Wang, Fang Bai, Gang Bai… in Protein & Cell (2011)

Article

Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA

Integrase plays a critical role in the recombination of viral DNA into the host genome. Therefore, over the past decade, it has been a hot target of drug design in the fight against type 1 human immunodeficien...

Xue Yao, Shasha Fang, Wentao Qiao, Yunqi Geng, Yuequan Shen in Protein & Cell (2010)