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Article
SOX5 Attenuates Toxicity in Neural Stem Cells Induced by Sevoflurane Anesthesia via Regulating the PI3K/AKT Pathway
Differentiation and self-renewal capacity of neural stem cells are essential for the development and function of brain. Anesthesia exposure inhibits the differentiation and self-renewal capacity of neural stem...
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Article
The energy cost and optimal design for synchronization of coupled molecular oscillators
A model of coupled molecular biochemical oscillators is proposed to study non-equilibrium thermodynamics of synchronization. Under general considerations, we find that chemical interactions within an ensemble ...
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Article
Open AccessDesign principles for enhancing phase sensitivity and suppressing phase fluctuations simultaneously in biochemical oscillatory systems
Biological systems need to function accurately in the presence of strong noise and at the same time respond sensitively to subtle external cues. Here we study design principles in biochemical oscillatory circu...
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Article
The free-energy cost of accurate biochemical oscillations
Oscillations within the cell regulate the timing of many important life cycles. However, in this noisy environment, oscillations can be highly inaccurate owing to phase fluctuations. It remains poorly understo...
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Article
Rational design of a biosensor circuit with semi-log dose-response function in Escherichia coli
A central goal of synthetic biology is to apply successful principles that have been developed in electronic and chemical engineering to construct basic biological functional modules, and through rational desi...
