60 Result(s)
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Open AccessNEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1
Ovarian endometriosis is a common gynecological disease, and one of its most significant symptoms is infertility. In patients with endometriosis, defects in endometrial decidualization lead to impaired endomet...
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PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense
Escherichia coli Septu system, an anti-phage defense system, comprises two components: PtuA and PtuB. PtuA contains an ATPase domain, while PtuB is predicted to function as a nuclease. Here we show that PtuA and ...
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A platform for whole-genome speed introgression from Aegilops tauschii to wheat for breeding future crops
Breeding new and sustainable crop cultivars of high yields and desirable traits has been a major challenge for ensuring food security for the growing global human population. For polyploid crops such as wheat,...
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Open AccessTranscription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis
Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and the response to chemotherapy drugs in cells. So far, there are poorly known mechanisms fo...
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Open AccessAuthor Correction: Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture
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Open AccessLongitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture
From childhood to adolescence, the spatiotemporal development pattern of the human brain white matter connectome and its underlying transcriptomic and cellular mechanisms remain largely unknown. With a longitu...
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Acaricidal activities of paeonol from Moutan Cortex, dried bark of Paeonia × suffruticosa, against the grain pest mite Aleuroglyphus ovatus (Acari: Acaridae)
Aleuroglyphus ovatus (Acari: Acaridae) is a major pest mite of stored grains that is distributed worldwide. Paeonol, a phenolic component of the essential oil extracted from the Chinese herb Paeonia moutan, posse...
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Carnosine alleviates kidney tubular epithelial injury by targeting NRF2 mediated ferroptosis in diabetic nephropathy
Diabetic nephropathy (DN) can promote the occurrence of end-stage renal disease (ESRD). The injury of renal tubular epithelial cells is a significant reason for the occurrence of ESRD. A recent research demons...
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Author Correction: In vitro expansion of human sperm through nuclear transfer
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Open AccessEfficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish
Natronobacterium gregoryi Argonaute (NgAgo) was found to reduce mRNA without generating detectable DNA double-strand breaks in a couple of endogenous genes in zebrafish, suggesting its potential as a tool for gen...
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Open AccessIntegrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation
Cryo-electron tomography (cryo-ET) is a revolutionary technique for resolving the structure of subcellular organelles and macromolecular complexes in their cellular context. However, the application of the cry...
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Open AccessGenome-wide identification and characterization of the bHLH gene family and analysis of their potential relevance to chlorophyll metabolism in Raphanus sativus L
Green-fleshed radish (Raphanus sativus L.) is an economically important root vegetable of the Brassicaceae family, and chlorophyll accumulates in its root tissues. It was reported that the basic helix-loop-helix ...
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Identification of cell types in multiplexed in situ images by combining protein expression and spatial information using CELESTA
Advances in multiplexed in situ imaging are revealing important insights in spatial biology. However, cell type identification remains a major challenge in imaging analysis, with most existing methods involvin...
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Total RNA Synthesis and its Covalent Labeling Innovation
RNA plays critical roles in a wide range of physiological processes. For example, it is well known that RNA plays an important role in regulating gene expression, cell proliferation, and differentiation, and m...
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Open AccessTargeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma
For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted inhibition of chemokines and their receptors is an ongoing a...
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Open AccessSalmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells
Salmonella is one of the most important worldwide zoonotic pathogens. After invading a host orally, the bacteria break through the intestinal epithelial barrier for further invasion. Intestinal epithelial cells (...
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TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization
Gasdermin-D (GSDMD), the executioner of pyroptotic cell death when it is cleaved by inflammatory caspases, plays a crucial role in host defense and the response to danger signals. So far, there are no known me...
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Cross-modal coherent registration of whole mouse brains
Recent whole-brain map** projects are collecting large-scale three-dimensional images using modalities such as serial two-photon tomography, fluorescence micro-optical sectioning tomography, light-sheet fluo...
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Open AccessPredicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines
Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to tran...
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Molecular-scale axial localization by repetitive optical selective exposure
We introduce an axial localization with repetitive optical selective exposure (ROSE-Z) method for super-resolution imaging. By using an asymmetric optical scheme to generate interference fringes, a <2 nm axial...
