95 Result(s)
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Yu. Li
Cell Biology
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Article
Open AccessZinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis
The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human health. Although more and more researches have confirmed the toxic effects of ZnO NPs, ...
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Open AccessTumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...
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Open AccessACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral am...
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Open AccessGLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma
While previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to discover if GLUT1 promotes tumor progression through a non-metabolic pathway.
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De novo transcriptome profiling reveals the patterns of gene expression in plum fruits with bud mutations
Bud mutation is a common technique for plant breeding and can provide a large number of breeding materials. Through traditional breeding methods, we obtained a plum plant with bud mutations (named “By”) from a...
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PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy
There is a lack of effective treatments to overcome resistance to EGFR-TKIs in EGFR mutant tumors. A deeper understanding of resistance mechanisms can provide insights into reducing or eliminating resistance, ...
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Liquiritin alleviates LPS-stimulated podocyte apoptosis and inflammation by activating Nrf2 signaling
The kidney is one of the most vulnerable organs during the pathogenesis of sepsis. Regulating podocyte injury may be helpful for the treatment of acute kidney injury (AKI) after sepsis. Liquiritin is a flavono...
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Cognitive Deficits and Alzheimer’s Disease-Like Pathologies in the Aged Chinese Tree Shrew
Alzheimer’s disease (AD) is the most common chronic progressive neurodegenerative disease in the elderly. It has an increasing prevalence and a growing health burden. One of the limitations in studying AD is t...
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Structure of GPR101–Gs enables identification of ligands with rejuvenating potential
GPR101 is an orphan G protein-coupled receptor actively participating in energy homeostasis. Here we report the cryo-electron microscopy structure of GPR101 constitutively coupled to Gs heterotrimer, which rev...
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Open AccessCOASY variant as a new genetic cause of riboflavin-responsive lipid storage myopathy
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Autophagy receptor OsNBR1 modulates salt stress tolerance in rice
Autophagy receptor OsNBR1 modulates salt stress tolerance by affecting ROS accumulation in rice.
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Open AccessIron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
Regulated cell death (RCD) is a regulable cell death that involves well-organized signaling cascades and molecular mechanisms. RCD is implicated in fundamental processes such as organ production and tissue rem...
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Open AccessSHMT2 regulates esophageal cancer cell progression and immune Escape by mediating m6A modification of c-myc
In recent years, the role of altered cellular metabolism in tumor progression has attracted widespread attention. Related metabolic enzymes have also been considered as potential cancer therapeutic targets. Se...
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Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles
Eukaryotic ribosome assembly is a highly orchestrated process that involves over two hundred protein factors. After early assembly events on nascent rRNA in the nucleolus, pre-60S particles undergo continuous ...
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Open AccessA novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection
Varicella zoster virus (VZV), which is a human restricted alpha-herpesvirus, causes varicella (chickenpox) and zoster (shingles). The subsequent post-herpetic neuralgia (PHN) due to VZV infection is excruciati...
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Open AccessNRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes
Injury or stress can induce intracellular translocation and release of nuclear HMGB1, a DAMP molecule known to participate in inflammation and other pathological processes. Active release of HMGB1 from stimula...
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Mitochondrial damage-induced abnormal glucose metabolism with ageing in the hippocampus of APP/PS1 mice
Accumulation of β-amyloid (Aβ) in neurons of patients with Alzheimer’s disease (AD) inhibits the activity of key enzymes in mitochondrial metabolic pathways, triggering mitochondrial dysfunction, which plays a...
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SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma
Aberrant SUMOylation contributes to the progression of hepatocellular carcinoma (HCC), yet the molecular mechanisms have not been well elucidated. RING-type E3 ubiquitin ligase RNF146 is a key regulator of the...
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Open AccessThe regulation loop of MARVELD1 interacting with PARP1 in DNA damage response maintains genome stability and promotes therapy resistance of cancer cells
The DNA damage response (DDR) plays crucial roles in cancer prevention and therapy. Poly(ADP-ribose) polymerase 1 (PARP1) mediates multiple signal transduction in the DDR as a master regulator. Uncovering the ...
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Highly Engrafting Cord Blood Hematopoietic Stem Cells are Enriched in CD34+ Cell Population with High Autophagy Activity
