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Open AccessPharmacokinetic/pharmacodynamic evaluation of gamithromycin against rabbit pasteurellosis
Gamithromycin is an effective therapy for bovine and swine respiratory diseases but not utilized for rabbits. Given its potent activity against respiratory pathogens, we sought to determine the pharmacokinetic...
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Article
Open AccessTwo somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma
The androgen receptor (AR) plays an important role in male-dominant hepatocellular carcinoma, and specific acquired somatic mutations of AR have been observed in HCC patients. Our previous research have establish...
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Open AccessSEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival
Hepatocellular carcinoma (HCC) metastasis and recurrence lead to therapy failure, which are closely associated with the proteome. However, the role of post-translational modification (PTM) in HCC, especially f...
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Open AccessConsistent explanation for the cosmic-ray positron excess in p-wave Breit–Wigner enhanced dark matter annihilation
Dark matter (DM) annihilation in the galactic halo can be enhanced relative to that in the early Universe due to the Breit–Wigner enhancement, if the DM particles annihilate through a narrow resonance. Althoug...
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Improved constraints on dark matter effective interactions from CDEX
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Open AccessCleaning the palate and tongue without nausea: a mixed methods study exploring the appropriate depth and direction of oral care
It is advisable to clean the palate and tongue thoroughly during oral care to protect against nosocomial infections. However, improper cleaning may cause nausea. To date, no robust data are available regarding...
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Open AccessEnvironmental remodeling of human gut microbiota and antibiotic resistome in livestock farms
Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes and bacteria. Here we study the impact of confined and controlled swine farm environments on temporal c...
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Open AccessEpidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets
Gamithromycin is a macrolide approved for the treatment of bovine and swine respiratory diseases. Our study aims to establish the clinical breakpoint and optimum dose regimen for gamithromycin against Haemophilus...
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Open AccessA core effector UV_1261 promotes Ustilaginoidea virens infection via spatiotemporally suppressing plant defense
False smut is a destructive grain disease of rice worldwide, characterized by false smut balls formed in rice flowers. Here we identified a small secreted protein UV_1261 contributing to virulence of Ustilaginoid...
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Open AccessPharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks
This study focused on utilizing pharmacokinetics/pharmacodynamics (PK/PD) modeling to optimize therapeutic dosage regimens of sarafloxacin against avian pathogenic Escherichia. coli O78 strain in Muscovy ducks. T...
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Open AccessIn vitro Dynamic Pharmacokinetic/Pharamcodynamic (PK/PD) study and COPD of Marbofloxacin against Haemophilus parasuis
Haemophilus parasuis (H. parasuis) can invade the body and cause systemic infection under stress conditions. Marbofloxacin has been recommended for the treatment of swine infections. H...
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Open AccessIn vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis
Haemophilus parasuis (H. parasuis) causes Glässer’s disease and multisystem infectious disease. It is one of the major causes of nursery mortality in swine herds. Cefquinome (CEQ) is proposed f...
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Open AccessStrongly first order phase transition in the singlet fermionic dark matter model after LUX
We investigate an extension of the standard model (SM) with a singlet fermionic dark matter (DM) particle which interacts with the SM sector through a real singlet scalar. The presence of a new scalar provides...
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Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/ Akt signaling pathways
To investigate the effects of Sonic hedgehog (shh) protein on bone marrow-derived endothelial progenitor cells (BM-EPC) proliferation, migration and vascular endothelial growth factor (VEGF) production, and th...