27 Result(s)
within
Yu-**ao Li
Pharmacy
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Article
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Astragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in C...
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Article
Bayesian Method of Borrowing Study-Level Historical Longitudinal Control Data for Mixed-Effects Models with Repeated Measures
Bringing historical control information into a new trial appropriately holds the promise of more efficient trial design with more accurate estimates, increased power, and fewer patients allocated to inefficaci...
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Article
Astragalus polysaccharide: a review of its immunomodulatory effect
The Astragalus polysaccharide is an important bioactive component derived from the dry root of Astragalus membranaceus. This review aims to provide a comprehensive overview of the research progress on the immunom...
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Article
Recent progresses in marine microbial-derived antiviral natural products
Viruses have always been a class of pathogenic microorganisms that threaten the health and safety of human life worldwide. However, for a long time, the treatment of viral infections has been slow to develop, ...
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Article
Dopamine enhancement of dextrorphan-induced skin antinociception in response to needle pinpricks in rats
Dextrorphan with long-acting local anesthetic effects did not cause system toxicity as fast as bupivacaine, while catecholamines (i.e., epinephrine) with the vasoconstrictive characteristics enhanced the effec...
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Article
Pharmacological evaluation of 9,10-dihydrochromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives as potent anti-inflammatory agent
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely administered drugs for the treatment of inflammation. However, they usually cause some unexpected side effects. Coumarins and their derivative...
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Article
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells
The antioxidant properties of alpha-lipoic acid (ALA) are associated with its ability to reduce iron in cells and tissues, which is partly due to its inhibiting effect on iron uptake from transferrin and its p...
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Article
Pestalotic acids A-I, antibacterial ambuic acid analogues, from a mycoparasite (Pestalotipsis sp. cr014) of Cronartium ribicola
The white pine blister rust caused by Cronartium ribicola is a severe disease of Pinus armandii Franch in Sichuan Province, China. A mycoparasite was isolated from aeciospore piles of C. ribicola and identified a...
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Article
Terpenoid composition and the anticancer activity of Acanthopanax trifoliatus
The petroleum ether and ethyl acetate fractions of extract from an edible and medicinal plant Acanthopanax trifoliatus were found to show significant inhibitory effects against SF-268, MCF-7, HepG2 and NCI-H460 c...
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Article
Inhibition of voltage-gated Na+ channels by hinokiol in neuronal cells
Hinokiol is a naturally occurring diterpenoid compound isolated from plants such as Taiwania cryptomerioides. Anti-oxidation, anti-cancer, and anti-inflammation effects of this compound have been reported. It is ...
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Article
Four pestalpolyols from a mycoparasite Pestalotipsis sp. PG52
A mycoparasite PG52 isolated from aeciospore piles of Aecidium pourthiaea was identified as Pestalotipsis sp. The chemical constituents of Pestalotipsis sp. PG52 were investigated. Four novel polyketides, named p...
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Article
Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques
The binding abilities of scutellarin (Scu) and scutellarein (Scue) with bovine serum albumin (BSA) were investigated using equilibrium dialysis, high performance liquid chromatography, fluorescence spectroscop...
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Article
Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities
Three novel alkaloids (1–3), together with nineteen known ones (4–22), were isolated from the bulbs of Lycoris longituba. Their structures were elucidated on the basis of extensive spectroscopic analyses, which b...
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Article
The protection of Rhein lysinate to liver in diabetic mice induced by high-fat diet and streptozotocin
Rhein lysinate (RHL) is the salt of lysine and rhein and the objective of this study was to investigate the protection of RHL to liver in diabetic mice. The model of type 2 diabetes was established by high-fat...
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Article
Anti-fibrotic effect of PF2401-SF, a standardized fraction of Salvia miltiorrhiza, in thioacetamide-induced experimental rats liver fibrosis
We previously reported the in vitro and in vivo hepatoprotective and anti-fibrotic effects of PF2401-SF, a standardized fraction of Salvia miltiorrhiza, against acute and subacute liver injury. The aim of this st...
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Article
Inhibitory effects of imperatorin on voltage-gated K+ channels and ATP-sensitive K+ channels
Imperatorin is a furocoumarin isolated from Angelica archangelica and Cnidium monnieri. It has multiple neuromodulatory actions such as anticonvulsant effects, anxiolytic effects and anti-nociceptive effects. Alt...
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Article
Pharmacokinetics of oxycodone hydrochloride and three of its metabolites after intravenous administration in Chinese patients with pain
The aim of this study is to evaluate the pharmacokinetic profile of oxycodone and three of its metabolites, noroxycodone, oxymorphone and noroxymorphone after intravenous administration in Chinese patients wit...
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Article
Simultaneous determination of five flavonoids during the growth of Fructus Sophorae by capillary electrophoresis
A method of simultaneous determination of five flavonoids during the growth of Fructus Sophorae by β-cyclodextrin (β-CD-) modified capillary zone electrophoresis was developed. The effects of various parameter...
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Article
Characterization of phenolic compounds from Rhododendron alutaceum
A new phenolic glycoside, 3′-keto rhododendrin (1) and a new sesquilignan, alutaceuol (2), together with twelve known phenolic compounds, were isolated from the leaves of Rhododendron alutaceum. Their structures ...
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Article
A novel 7-O-modified genistein derivative with acetylcholinesterase inhibitory effect, estrogenic activity and neuroprotective effect
To find the multi-target-directed compounds for the treatment of Alzheimer’s disease (AD), we synthesized 7-(4-(diethylamino)butoxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, a novel 7-O-modified geniste...
