6 Result(s)
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Yper Hall
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessSerological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea
Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. To characterise filovirus zoonotic exposure, we collected cr...
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Open AccessA potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanob...
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Open AccessComparison of rhesus and cynomolgus macaques as an infection model for COVID-19
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis o...
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Open AccessDose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-CoV-2 in the ferret model....
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Open AccessPseudoty** of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies
Ebola virus (EBOV) is an enveloped, single-stranded RNA virus that can cause Ebola virus disease (EVD). It is thought that EVD survivors are protected against subsequent infection with EBOV and that neutralisi...
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Open AccessTemporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa.
