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Article
Open AccessSynthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast u...
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Article
Open AccessTreatment with the IDO inhibitor INCB024360 increased lysis of human tumor cell targets by peptide-specific CTL
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Article
An overview of targeted alpha therapy
The effectiveness of targeted α-therapy (TAT) can be explained by the properties of α-particles. Alpha particles are helium nuclei and are ~8,000 times larger than β−-particles (electrons). When emitted from radi...
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Article
Impact of bifunctional chelators on biological properties of 111In-labeled cyclic peptide RGD dimers
The present study describes the synthesis and biological evaluation of 111In(DOTA-3P-RGD2) (DOTA = 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid; 3P-RGD2 = PEG4-E[PEG4-c(RGDfK)]2; PEG4 = 15-amino-4,7,...
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Article
99mTcO(MAG2-3G3-dimer): a new integrin αvβ3-targeted SPECT radiotracer with high tumor uptake and favorable pharmacokinetics
This report presents the synthesis of a cyclic RGD dimer conjugate, MAG2-G3-E[G3-c(RGDfK)]2 (MAG2-3G3-dimer, G3 = Gly-Gly-Gly, MAG2 = S-benzoyl mercaptoacetylglycylglycyl), and evaluation of its 99mTc complex, 99...