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Article
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
The structure of the ligand-free HIV-1–Env trimer allows conformational fixation of Env and generation of an antigen that binds CD4 with high affinity and is recognized by broadly neutralizing antibodies but n...
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Chapter and Conference Paper
Single-Port Surgical Robot System with Flexible Surgical Instruments
This paper presents a new novel SINGLE-PORT access surgery (SPS) robot system. This surgical robot is composed of a surgical slave robot with flexible surgical instruments and an ergonomic master device with a...
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Article
Open AccessMicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance
Ovarian carcinoma is the leading cause of cancer death worldwide among gynecological malignancies, and the majority of cases are related with recurrence and chemoresistance. Cancer stem cells (CSCs) are believ...
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Article
Open AccessEffects of corticosteroid on the expressions of neuropeptide and cytokine mRNA and on tenocyte viability in lateral epicondylitis
The purpose of this study was to determine the reaction mechanism of corticosteroid by analyzing the expression patterns of neuropeptides (substance P (SP), calcitonin gene related peptide (CGRP)) and of cytok...
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Article
Synthesis and properties of polycarbonate-co-poly(siloxane-urethane-siloxane) block copolymers
Polycarbonate-co-poly(siloxane-urethane-siloxane) block copolymers (SiUrPC) were synthesized from siloxane-urethane monomer and polycarbonate (PC) oligomer, and their properties were compared with those of lin...
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Article
Synthesis and characterization of polycarbonates containing terminal and chain interior siloxane
Silicone polycarbonates having polydimethyl siloxane (PDMS) and heptamethyl trisiloxane (HMTS) were synthesized by the interfacial polymerization. Instead of common chain terminator p-tert-butyl phenol (PTBP), eu...
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Article
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary s...
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Article
Association of the vascular endothelial growth factor (VEGF-1154G>A) polymorphism in patients with colorectal cancer
Angiogenesis plays a pivotal role in the development of colon cancer during the promotion and metastasis of tumor growth. Vascular endothelial growth factor (VEGF) is known to be a potent angiogenic factor. Th...
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Article
The molecular signature of in vitro senescence in human mesenchymal stem cells
We investigated the molecular characteristics of in vitro senescence in human bone marrow-derived mesenchymal stem cells. After prolonged in vitro expansion, MSCs underwent cellular senescence characterized by gr...
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Chapter
Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses
Structural biology provides a wealth of information about the three-dimensional organization and chemical makeup of proteins. An understanding of atomic-level structure offers enormous potential to design rati...
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Article
Correction: Corrigendum: Human zinc fingers as building blocks in the construction of artificial transcription factors
Nat. Biotechnol. 21, 275–280 (2003) An author's name was misspelled. Soon Hyung Sohn should be Joon Hyung Sohn.
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Article
Human zinc fingers as building blocks in the construction of artificial transcription factors
We describe methods for generating artificial transcription factors capable of up- or downregulating the expression of genes whose promoter regions contain the target DNA sequences. To accomplish this, we scre...
