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Article
Combined effects of microplastics and methylmercury on the activity of ATP-binding cassette (ABC) transporter in the brackish water flea Diaphanosoma celebensis
Due to their widespread presence, persistence, and bioaccumulation in living organisms, microplastics (MP) and methylmercury (MeHg) pollution pose a threat to aquatic organisms. ATP cassette-binding (ABC) prot...
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Article
Metabolomic analysis of combined exposure to microplastics and methylmercury in the brackish water flea Diaphanosoma celebensis
Owing to their widespread distribution and high bioaccumulation, microplastics (MPs) and mercury (Hg) are considered major threats to the ocean. MP interacts with Hg because of its high adsorption properties. ...
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Article
Production of Tagatose by Whole-cell Bioconversion from Fructose Using Corynebacterium glutamicum
Tagatose is a rarely occurring sugar found in food and sweet fruits. It is a potential sweetener with low calories but a sweetness similar to that of sucrose. In this study, we developed a whole-cell biocataly...
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Article
Open AccessValidation of reference genes for quantitative real-time PCR in chemical exposed and at different age’s brackish water flea Diaphanosoma celebensis
Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), a primary approach for evaluating gene expression, requires an appropriate normalization strategy to confirm relative gene expr...
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Article
Open AccessTarget modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection
The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al. Arthritis Res. Ther. 18, 91, ...
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Article
Identification of ecdysteroid pathway-related genes and their transcriptional modulation in the brackish water flea Diaphanosoma celebensis exposed to bisphenol analogs
Ecdysone plays a crucial role in the molting process, is synthesized by neverland (nvd) and regulates the transcription of early response genes, HR3 and E75. However, their roles in the development and reproducti...
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Article
Effects of heavy metals on the expression of digestive enzyme-coding genes in the brackish water flea Diaphanosoma celebensis
Energy metabolism is an essential physiological event for all life forms, and, in heterotrophic organisms, it significantly depends on food intake. Digestive enzymes play an important role in acquiring the nut...
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Article
Modulation of glutathione S-transferase and superoxide dismutase in response to heavy metals in brackish water flea Diaphanosoma celebensis
Superoxide dismutase (SOD) and glutathione S-transferase (GST) serve as biomarkers of oxidative stress in aquatic organisms. However, the modulatory effects of heavy metals on the expression of small crustaceans ...
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Article
Open AccessClean interface without any intermixed state between ultra-thin P3 polymer and CH3NH3PbI3 hybrid perovskite thin film
Hole transport layers (HTL) are crucial materials to improve the power conversion efficiency in organohalide hybrid perovskite-based solar-cell applications. Two important physical properties are required in H...
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Article
Open AccessSignificant THz absorption in CH3NH2 molecular defect-incorporated organic-inorganic hybrid perovskite thin film
The valid strong THz absorption at 1.58 THz was probed in the organic-inorganic hybrid perovskite thin film, CH3NH3PbI3, fabricated by sequential vacuum evaporation method. In usual solution-based methods such as...
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Article
Evaluation of 4-nonylphenol and bisphenol A toxicity using multiple molecular biomarkers in the water flea Daphnia magna
Alkylphenols are well-known endocrine disruptors and may cause developmental and reproductive disorders in aquatic organisms. Daphnia magna is commonly used in ecotoxicological studies as a promising model specie...
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Article
Open AccessDe novo transcriptome assembly of brackish water flea Diaphanosoma celebensis based on short-term cadmium and benzo[a]pyrene exposure experiments
To develop a brackish water flea as a promising model for marine monitoring, Diaphanosoma celebensis were exposed to two pollutants, cadmium (Cd) and benzo[a]pyrene (BaP), which have different chemical characteri...
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Article
Open AccessInhibitory effects of Euphorbia supina on Propionibacterium acnes-induced skin inflammation in vitro and in vivo
Euphorbia supina (ES) plant has been used as treatment for inflammatory conditions. The antibacterial effect and the anti-inflammatory mechanism of ES for Propionibacterium (P.) acnes-induced inflammation in THP-...
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Article
Open AccessAntioxidant and skin-whitening effects of aerial part of Euphorbia supina Raf. Extract
Euphorbia supina (ES) has been widely used in folk medicine owing to its antibacterial, hemostatic, and anti-inflammatory properties. The aim of this study was to evaluate the antioxidant and skin-whitening effec...
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Article
Acute Toxicity and Modulation of an Antioxidant Defence System in the Brackish Water Flea Diaphanosoma celebensis Exposed to Cadmium and Copper
Heavy metals are one of the greatest concerns for aquatic ecosystems, as land-derived contaminants continuously flow into estuaries and coastal regions. Thus, there is a need to develop robust model species fo...
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Article
Open AccessComplement C1q stimulates the progression of hepatocellular tumor through the activation of discoidin domain receptor 1
C1q is known to perform several functions in addition to the role it plays in complement activation. C1q contains a collagen-like portion and DDR1 (discoidin domain receptor 1) is a well-known collagen recepto...
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Article
Transcriptional profiling of antioxidant defense system and heat shock protein (Hsp) families in the cadmium- and copper-exposed marine ciliate Euplotes crassu
To understand the transcriptional response of antioxidant defense system and heat shock protein (Hsp) families of the marine ciliate Euplotes crassus, we analyzed the transcriptome profile using RNA-seq technolog...
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Article
Changes in activity and transcription of antioxidant enzymes and heat shock protein 90 in the water flea, Daphnia magna - exposed to mercury
Mercury (Hg) has adverse effects in aquatic organisms but mechanisms underlying the effects of Hg in aquatic invertebrates are unclear. To investigate the oxidative stress response in the water flea Daphnia magna
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Article
Open AccessHM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus
Systemic lupus erythematosus (SLE) is associated with B cell hyperactivity, and lupus nephritis (LN), in particular, is promoted by the production of autoantibodies and immune complex deposition. Bruton’s tyro...
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Article
Transcriptome profiles of Daphnia magna across to the different water chemistry of surface water of the Korean Demilitarized Zone
The Korean Demilitarized Zone (DMZ) has almost completely protected surface water conditions. Despite the water conditions of DMZ are excellent clear, downstream of river or natural irrigation ponds near the r...
