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  1. No Access

    Article

    Combining E-ice-COLD-PCR and Pyrosequencing with Di-Base Addition (PDBA) Enables Sensitive Detection of Low-Abundance Mutations

    Detecting low-abundance mutations is of particular interest in the fields of biology and medical science. However, most currently available molecular assays have limited sensitivity for the detection of low-ab...

    Dan Pu, Huimin Chen, Wenjuan Fu, Youhong Cui… in Applied Biochemistry and Biotechnology (2024)

  2. Article

    Open Access

    Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

    Medulloblastoma (MB) is one of the most common childhood malignant brain tumors (WHO grade IV), traditionally divided into WNT, SHH, Group 3, and Group 4 subgroups based on the transcription profiles, somatic ...

    Yan-**a Wang, Haibo Wu, Yong Ren, Shengqing Lv… in Signal Transduction and Targeted Therapy (2022)

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    Article

    Combination of p38 MAPK inhibitor with PD-L1 antibody effectively prolongs survivals of temozolomide-resistant glioma-bearing mice via reduction of infiltrating glioma-associated macrophages and PD-L1 expression on resident glioma-associated microglia

    Current conventional treatment strategies for glioblastoma (GBM) have limited efficacy due to the rapid development of resistance to temozolomide (TMZ). It is particularly urgent to develop novel therapeutic s...

    Weiqi Dang, **gfang **ao, Qinghua Ma, **gya Miao, Mianfu Cao… in Brain Tumor Pathology (2021)

  4. Article

    Open Access

    Autofluorescence of NADH is a new biomarker for sorting and characterizing cancer stem cells in human glioma

    The existing cell surface markers used for sorting glioma stem cells (GSCs) have obvious limitations, such as vulnerability to the enzymatic digestion and time-consuming labeling procedure. Reduced nicotinamid...

    Ye Yuan, Zexuan Yan, **gya Miao, Ruili Cai, Mengsi Zhang… in Stem Cell Research & Therapy (2019)

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  5. Article

    Open Access

    Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/β-catenin pathway

    A growing body of evidence shows that the development and progression of gastric cancer (GC) is mainly associated to the presence of gastric cancer stem-like cells (GCSLCs). However, it is unclear how GCSLC po...

    Chengdong Ji, Lang Yang, Wei**g Yi, Dongfang **ang, Yanxia Wang, Zhihua Zhou… in Oncogene (2018)

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  6. No Access

    Article

    Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model

    It has been demonstrated that numerous microRNAs (miRNAs) have potent tumor-suppressing effects on a variety of cancers, implicating a possible application of miRNA in tumor therapy. Oncolytic adenovirus is a ...

    Wenjia Lou, Qing Chen, Leina Ma, Jia Liu, Zhi Yang… in Journal of Molecular Medicine (2013)

  7. No Access

    Article

    Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFα response and p53 activity

    Non-structural protein 1 (NS1) is an important virulence factor of the highly pathogenic H5N1 avian influenza virus. A five-amino-acid (5 aa) deletion at position 80–84 and an aspartic acid to glutamic acid su...

    Weizhong Li, Gefei Wang, Heng Zhang, Gang **n… in Cellular & Molecular Immunology (2010)