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  1. No Access

    Article

    Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

    Activation of receptor protein kinases is prevalent in various cancers with unknown impact on ferroptosis. Here we demonstrated that AKT activated by insulin-like growth factor 1 receptor signalling phosphoryl...

    Ke Wu, Meisi Yan, Tong Liu, Zheng Wang, Yuran Duan, Yan **a… in Nature Cell Biology (2023)

  2. Article

    Open Access

    Governing glutaminolysis by regulation of glutaminase succinylation

    Qingxia Ma, Hongfei Jiang, Leina Ma, Ying Meng, Dong Guo, Yingying Tong… in Protein & Cell (2022)

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  3. No Access

    Article

    Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

    Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumou...

    Yang Gao, Naoe Taira Nihira, **a Bu, Chen Chu, **fang Zhang… in Nature Cell Biology (2020)

  4. No Access

    Article

    E3 ubiquitin ligases in cancer and implications for therapies

    E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their degradation, which are of importance in cellular homeostasis. Since many oncogenic or tumor-suppressive proteins are report...

    Dong Wang, Leina Ma, Bin Wang, Jia Liu, Wenyi Wei in Cancer and Metastasis Reviews (2017)

  5. No Access

    Article

    ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway

    Oleanolic acid (OA) is a natural triterpenoid that is widely distributed in edible and medicinal plants. OA exerts anti-tumor activity on a wide range of cancer cells primarily through inducing apoptosis. Dysr...

    Jia Liu, Leina Ma, **ao Chen, Jianxun Wang, Tao Yu, Ying Gong, Aiguo Ma… in Tumor Biology (2016)

  6. No Access

    Article

    MAPK/ERK signaling pathway-induced hyper-O-GlcNAcylation enhances cancer malignancy

    Dysregulated MAPK/ERK signaling is implicated in one-third of human tumors and represents an attractive target for the development of anticancer drugs. Similarly, elevated protein O-GlcNAcylation and O-GlcNAc...

    **nling Zhang, Leina Ma, Jieqiong Qi, Hui Shan… in Molecular and Cellular Biochemistry (2015)

  7. No Access

    Article

    p38 MAPK-dependent Nrf2 induction enhances the resistance of glioma cells against TMZ

    Temozolomide (TMZ) is an effective agent for clinical glioma treatment, but the innate and acquired resistance of glioma always limits its application. Although some advances have been achieved to elucidate th...

    Leina Ma, Jia Liu, **nling Zhang, Jieqiong Qi, Wengong Yu, Yuchao Gu in Medical Oncology (2015)

  8. No Access

    Article

    Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model

    It has been demonstrated that numerous microRNAs (miRNAs) have potent tumor-suppressing effects on a variety of cancers, implicating a possible application of miRNA in tumor therapy. Oncolytic adenovirus is a ...

    Wenjia Lou, Qing Chen, Leina Ma, Jia Liu, Zhi Yang… in Journal of Molecular Medicine (2013)

  9. No Access

    Article

    A novel strategy for cancer treatment: Targeting cancer stem cells

    Cancer stem cell/tumor-initiating cell (CSC/TIC) is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recu...

    Jia Liu, LeiNa Ma, YiGang Wang, **nYuan Liu, QiJun Qian in Chinese Science Bulletin (2008)