36 Result(s)

Article

Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca²⁺-dependent PKC isoforms

Prolactin promotes proliferation of several cells. Prolactin receptor exists as two isoforms: long and short, which activate different transduction pathways including the Ca²⁺-dependent PKC-signaling. No informat...

Silvia Taffetani, Shannon Glaser, Heather Francis, Sharon DeMorrow… in BMC Physiology (2007)

Article

Impaired mitochondrial β-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance

Hepatic steatosis is often seen in patients with chronic hepatitis C (CH-C). It is still unclear whether these patients have an impaired mitochondrial β-oxidation. In this study we assessed mitochondrial β-oxi...

Chikako Sato, Takafumi Saito, Keiko Misawa, Tomohiro Katsumi… in BMC Gastroenterology (2013)

Article

Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell

An imbalance of plasma amino acids (AA) is observed cirrhotic patients. Here we report that the imbalance suppresses the maturation of dendritic cells (DCs) by reducing the intracellular ATP due to interferenc...

Eiji Kakazu, Yasuteru Kondo, Takayuki Kogure, Masashi Ninomiya… in Scientific Reports (2013)

Article

Erratum to: A thymine–adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus

Satoshi Hiramine, Masaya Sugiyama, Norihiro Furusyo… in Journal of Gastroenterology (2016)

Article

Predictors for mortality from respiratory failure in a general population

Risk factors for death from respiratory failure in the general population are not established. The aim of this study was to determine the characteristics of individuals who die of respiratory failure in a Japa...

Maki Kobayashi, Yoko Shibata, Sumito Inoue, Akira Igarashi… in Scientific Reports (2016)

Article

Evidence-based clinical practice guidelines for liver cirrhosis 2015

The Japanese Society of Gastroenterology revised the evidence-based clinical practice guidelines for liver cirrhosis in 2015. Eighty-three clinical questions were selected, and a literature search was performe...

Hiroshi Fukui, Hidetsugu Saito, Yoshiyuki Ueno, Hirofumi Uto… in Journal of Gastroenterology (2016)

Article

Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study

Albuminuria and proteinuria are known risk factors for premature death. This study compared the ability of albuminuria and proteinuria to predict mortality in a community-based population.

Hiroko Sato, Tsuneo Konta, Kazunobu Ichikawa… in Clinical and Experimental Nephrology (2016)

Article

Diagnosis and treatment of eosinophilic esophagitis in clinical practice

Eosinophilic esophagitis (EoE) is a chronic and abnormal Th2 type immunological response characterized by intense eosinophilic inflammation localized within the esophagus. This leads to esophageal dysfunction ...

Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Takao Yaoita… in Clinical Journal of Gastroenterology (2017)

Article

Non-autotrophic methanogens dominate in anaerobic digesters

Anaerobic digesters are man-made habitats for fermentative and methanogenic microbes, and are characterized by extremely high concentrations of organics. However, little is known about how microbes adapt to su...

Atsushi Kouzuma, Maho Tsutsumi, Shun’ichi Ishii, Yoshiyuki Ueno… in Scientific Reports (2017)

Article

A new polymethylmetacrylate membrane improves the membrane adhesion of blood components and clinical efficacy

Hemodialysis with polymethylmetacrylate (PMMA) membrane dialyzers allows unique protein adsorption. New PMMA dialyzers should demonstrate equivalent protein adsorption, but improved hemocompatibility.

Ikuto Masakane, Shiho Esashi, Asami Yoshida, Tetsuro Chida… in Renal Replacement Therapy (2017)

Article

Sofosbuvir–velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 hepatitis C who failed direct-acting antivirals

In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir–velpa...

Namiki Izumi, Tetsuo Takehara, Kazuaki Chayama… in Hepatology International (2018)

Article

Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis

Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have...

Minami Yagi, Atsushi Tanaka, Masanori Abe, Tadashi Namisaki… in Scientific Reports (2018)

Article

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers

Insulin signals, via the regulation of key enzyme expression, both suppress gluconeogenesis and enhance lipid synthesis in the liver. Animal studies have revealed insulin signaling favoring gluconeogenesis sup...

Midori Honma, Shojiro Sawada, Yoshiyuki Ueno… in International Journal of Obesity (2018)

Article

Efficacy and safety of sofosbuvir–velpatasvir with or without ribavirin in HCV-infected Japanese patients with decompensated cirrhosis: an open-label phase 3 trial

In Japan, hepatitis C virus (HCV)-infected patients with decompensated cirrhosis currently have no treatment options. In this Phase 3 study, we evaluated sofosbuvir–velpatasvir with or without ribavirin for 12...

Tetsuo Takehara, Naoya Sakamoto, Shuhei Nishiguchi… in Journal of Gastroenterology (2019)

Article

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our previous genome-wide association study (GWAS) identified ...

Yuki Hitomi, Kazuko Ueno, Yosuke Kawai, Nao Nishida, Kaname Kojima… in Scientific Reports (2019)

Article

Efficiency score from data envelopment analysis can predict the future onset of hypertension and dyslipidemia: A cohort study

Primary prevention focuses on ensuring that healthy people remain healthy. As it is practically difficult to provide intervention for an entire healthy population, it is essential to identify and target the at ri...

Sho Nakamura, Hiroto Narimatsu, Yoshinori Nakata, Masahiko Sakaguchi… in Scientific Reports (2019)

Article

Steeper steps and pledge for inevitable responsibilities

Yoshiyuki Ueno, Hiroshi Seno in Journal of Gastroenterology (2020)

Article

Transition in the etiology of liver cirrhosis in Japan: a nationwide survey

To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH).

Hirayuki Enomoto, Yoshiyuki Ueno, Yoichi Hiasa… in Journal of Gastroenterology (2020)

Article

Association among chronic kidney disease, airflow limitation, and mortality in a community-based population: The Yamagata (Takahata) study

Chronic kidney disease (CKD) and chronic obstructive pulmonary disease (COPD) are known risk factors for mortality. In this study, we examined the overlap of CKD and airflow limitation (AFL) that characterises...

Natsuko Suzuki, Eri Matsuki, Akira Araumi, Sakiko Ashitomi… in Scientific Reports (2020)

Article

Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies

Signet-ring cell carcinoma of the ampulla of Vater is a rare tumor. A 74-year-old woman presented with epigastric pain and was diagnosed with cholangitis. Her liver enzyme levels were elevated. Computed tomogr...

Chisaki Ikeda, Naohiko Makino, Akiko Matsuda… in Clinical Journal of Gastroenterology (2020)