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  1. Article

    Open Access

    C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene

    Insulin interacts with the insulin receptor, and the activated receptor promotes activity of the phosphoinositide-3 kinase (PI3K) enzyme. A decrease in insulin or insulin-like growth factor 1 (IGF-1) signaling...

    Yoshio Kano, Fukumi Hiragami, Hirotoshi Motoda, Junichi Akiyama in Scientific Reports (2019)

  2. No Access

    Article

    Mechanism of differential Giemsa method for sister chromatids

    THE 33258 Hoechst fluorescence1 and 33258 Hoechst–Giemsa2 methods for differential staining of bromodeoxy-uridine (BrdU)-incorporated chromatids are attractive because of their rapidity and high sensitivity in re...

    TAKETOSHI SUGIYAMA, KEIKO GOTO, YOSHIO KANO in Nature (1976)