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  1. Article

    Open Access

    Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

    Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of PMD remain largely unknown except for recovery or death. In...

    Kojiro Suda, Yohsuke Moriyama, Nurhanani Razali, Yatzu Chiu… in Nature Aging (2024)

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    Article

    LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits

    Protein misfolding is a major factor of neurodegenerative diseases. Post-mitotic neurons are highly susceptible to protein aggregates that are not diluted by mitosis. Therefore, post-mitotic cells may have a s...

    Dan Li, Yoshikazu Johmura, Satoru Morimoto, Miyuki Doi, Keiko Nakanishi… in Nature Aging (2023)

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    Molecular Insights into the Regulation of Apoptosis and Cellular Senescence and Their Implications for Cancer

    Eukaryotic cells continuously encounter DNA damage caused by uncontrolled DNA replication and several sources of genotoxic stresses such as ultraviolet or ionizing irradiation. The cells have acquired the surv...

    Yoshikazu Johmura, Makoto Nakanishi in DNA Replication, Recombination, and Repair (2016)

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    Article

    Polo-box domain: a versatile mediator of polo-like kinase function

    Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo...

    Jung-Eun Park, Nak-Kyun Soung, Yoshikazu Johmura… in Cellular and Molecular Life Sciences (2010)