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Open AccessPancreatic cancer cell- and cancer-associated fibroblast-derived exosomes in disease progression, metastasis, and therapy
Exosomes play a crucial role in the progression and spread of pancreatic cancer, serving not only as promoters of tumor growth and organ-specific metastasis but also as promising biomarkers and targets for tre...
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Living Reference Work Entry In depth
Immunotherapy for Pancreatic Cancer
Pancreatic cancer is currently the fourth leading cause of cancer-related deaths with a high fatality rate, and is predicted to become the second leading cause of cancer mortality in the United States by 2030....
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Article
Open AccessAnalysis of genomic alterations in cancer associated human pancreatic stellate cells
Pancreatic stellate cells (PSCs) constitute important cells of the pancreatic microenvironment and their close interaction with cancer cells is important in pancreatic cancer. It is currently not known whether...
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Article
Open AccessIdentification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis
Pancreatic cancer is the fourth leading cause of cancer deaths in the United States both in females and in males, and is projected to become the second deadliest cancer by 2030. The overall 5-year survival rat...
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Chapter
Targeting Metabolism
For cell growth and proliferation, synthesis of cellular components such as DNA, proteins, and lipids is a prerequisite. Cells have to rewire and reprogram their metabolism to allow the production of required ...
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Article
Open AccessOncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic ce...
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Article
Open AccessPeroxisome Proliferator-Activated Receptor gamma negatively regulates liver regeneration after partial hepatectomy via the HGF/c-Met/ERK1/2 pathways
Peroxisome Proliferator-Activated Receptor gamma (PPARγ) is a nuclear receptor demonstrated to play an important role in various biological processes. The aim of this study was to determine the effect of PPARγ...
