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  1. Article

    Open Access

    Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles

    The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell cytoskeleton, growth and fibrosis. The role ...

    Shidong Shan, Min Su, Yan Li, Zhen Wang, Daoquan Liu, Yongying Zhou… in Molecular Medicine (2023)

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  2. Article

    Open Access

    Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate

    Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expr...

    Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang… in Journal of Translational Medicine (2023)

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  3. Article

    Open Access

    Glucose-regulated protein 78 modulates cell growth, epithelial–mesenchymal transition, and oxidative stress in the hyperplastic prostate

    Benign prostatic hyperplasia (BPH) is a chronic condition which mainly affects elderly males. Existing scientific evidences have not completely revealed the pathogenesis of BPH. Glucose-regulated protein 78 (G...

    Xun Fu, Jianmin Liu, Daoquan Liu, Yongying Zhou, Yuhang Guo… in Cell Death & Disease (2022)

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