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within Yongsik Cho Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

    Chondrosarcomas, malignant cartilaginous neoplasms, are capable of transitioning to highly aggressive, metastatic, and treatment-refractory states, resulting in significant patient mortality. Here, we aim to u...

    Hyeonkyeong Kim, Yongsik Cho, Hyeon-Seop Kim, Donghyun Kang… in Nature Communications (2020)

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  2. Article

    Open Access

    Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

    Osteoarthritis (OA) is a prevalent degenerative disease, which involves progressive and irreversible destruction of cartilage matrix. Despite efforts to reconstruct cartilage matrix in osteoarthritic joints, i...

    Sukyeong Kim, Sangbin Han, Yeongjae Kim, Hyeon-Seop Kim… in Nature Communications (2019)

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