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Article

Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

Osteoarthritis (OA) is a prevalent degenerative disease, which involves progressive and irreversible destruction of cartilage matrix. Despite efforts to reconstruct cartilage matrix in osteoarthritic joints, i...

Sukyeong Kim, Sangbin Han, Yeongjae Kim, Hyeon-Seop Kim… in Nature Communications (2019)