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  1. Article

    Open Access

    Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

    Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...

    Zhenglong Guo, Yongchang Zhu, Hai **ao, Ranran Dai, Wenke Yang… in Biological Research (2023)

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  2. Article

    Open Access

    Downregulation by CNNM2 of ATP5MD expression in the 10q24.32 schizophrenia-associated locus involved in impaired ATP production and neurodevelopment

    Genome-wide association studies (GWAS) have accelerated the discovery of numerous genetic variants associated with schizophrenia. However, most risk variants show a small effect size (odds ratio (OR) <1.2), su...

    Zhongju Wang, Yongchang Zhu, Linyan Ye, Qiyang Li, Bo Guo, Hao Zhao… in npj Schizophrenia (2021)

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