19 Result(s)

Article

Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis

Circular RNAs (circRNAs) are single-stranded RNAs with covalently closed structures that have been implicated in cancer progression. However, the regulatory mechanisms remain largely unclear. So, the aim of th...

Mingming **, Tailei Yuan, Kaisai Tian, **g**g Li… in Cellular & Molecular Biology Letters (2024)

Article

First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study

Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apati...

**aofeng Chen, Hao Xu, **aobing Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Migrasomes, a new mode of intercellular communication

Migrasomes are newly discovered extracellular vesicles (EVs) that are formed in migrating cells and mediate intercellular communication. However, their size, biological generation, cargo packaging, transport, ...

Yuyun Jiang, ** Liu, Jixian Ye, Yongbin Ma, Jiahui Mao… in Cell Communication and Signaling (2023)

Article

USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

Ubiquitin-specific protease 39(USP39) plays an important role in modulating pre-mRNA splicing and ubiquitin-proteasome dependent proteolysis as a member of conserved deubiquitylation family. Accumulating evide...

Weiwei Wang, Yongbin Lei, Gongye Zhang, **aomei Li, Jiahui Yuan… in Cell Death & Disease (2023)

Article

MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling

The incidence of cutaneous melanoma (CM) has been increasing annually worldwide. In this study, we identify that MrgprF, a MAS related GPR family member, is decreased in cutaneous melanoma tissues and cell lin...

Qiushuo Shen, Yanfei Han, Kai Wu, Yaomei He… in Signal Transduction and Targeted Therapy (2022)

Article

Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma

Emerging evidence suggests that USP39 plays an important role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanism by which USP39 promotes HCC progression has not been well de...

**aomei Li, Jiahui Yuan, Conghua Song, Yongbin Lei… in Cell Death & Differentiation (2021)

Article

miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer

Qiuxia **ong, Li** Jiang, Kun Liu… in Signal Transduction and Targeted Therapy (2021)

Article

The role of m6A modification in the biological functions and diseases

N⁶-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m....

**ulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan… in Signal Transduction and Targeted Therapy (2021)

Article

Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6

A growing number of circular RNAs (circRNAs) have been identified and verified in several cancers. However, highly efficient therapeutic methods based on circRNAs in lung cancer remain largely unexplored. In t...

Yongbin Chi, Wenlong Zheng, Guangyu Bao, Lifeng Wu, **aoxue He… in Cell Death & Disease (2021)

Article

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models of allergic asthma. Oxygen...

Liyang Dong, Ying Wang, Tingting Zheng, Yanan Pu… in Stem Cell Research & Therapy (2021)

Article

Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT

Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a key mechanism in pulmonary arterial hypertension (PAH). Serotonin (5-hydroxytryptamine, 5-HT) can induce abnormal proliferation of P...

Ying Zhang, Yongbin Chen, Guo Chen, Yingling Zhou… in Cellular & Molecular Biology Letters (2020)

Article

Stem cell therapies for periodontal tissue regeneration: a network meta-analysis of preclinical studies

Periodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive compa...

Qiang Li, Guangwen Yang, Jialing Li, Meng Ding, Na Zhou… in Stem Cell Research & Therapy (2020)

Article

hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice

Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury. Extracellular vesicles (EVs) are membranous vesicles release...

Liyang Dong, Yanan Pu, **aojun Chen, **n Qi, Lina Zhang… in Stem Cell Research & Therapy (2020)

Article

Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma

The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a sub...

Zhihong Yao, Lei Han, Yongbin Chen, Fei He, Bin Sun, Santosh kamar… in Cell Death & Disease (2018)

Article

Expression of MACC1 and c-Met in human gastric cancer and its clinical significance

Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role i...

Tiankang Guo, **gyu Yang, Jibin Yao, Yongbin Zhang, Mingxu Da… in Cancer Cell International (2013)

Article

A specific miRNA signature promotes radioresistance of human cervical cancer cells

The mechanisms responsible for cervical cancer radioresistance are still largely unexplored. The present study aimed to identify miRNAs associated with radioresistance of cervical cancer cells.

Bin Zhang, Jun Chen, Zhenghua Ren, Yongbin Chen, **hui Li… in Cancer Cell International (2013)

Article

Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration

Intestinal stem cells (ISCs) in the Drosophila adult midgut are essential for maintaining tissue homeostasis, and their proliferation and differentiation speed up in order to meet the demand for replenishing the ...

Fangfang Ren, Qing Shi, Yongbin Chen, Alice Jiang, Y Tony Ip, Huaqi Jiang… in Cell Research (2013)

Article

Decoding the phosphorylation code in Hedgehog signal transduction

Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis, and its deregulation leads to numerous human disorders including cancer. Binding of Hh to Patched (Ptc), a twe...

Yongbin Chen, ** Jiang in Cell Research (2013)

Article

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis in species ranging from Drosophila to mammals. The Hh signal is transduced by Smoothened (Smo), a seven-transmembr...

Cui** Yang, Wenlin Chen, Yongbin Chen, ** Jiang in Cell Research (2012)